Research Project Updates - Past, Present & Future

General guidelines for Research Project Updates (RPU) group meetings are:

• Please present the background of your research project (5 relevant slides, starting with a title and your scientific hypothesis, and updated with new material – don't simply recycle the same background slides), followed by the new results you obtained since the last RPU (5 slides; should also not have slide repetitions, but instead focus on the new research challenges you encountered, and how you solved them), and finish by presenting your plans for continuation of your experiments (5 slides; this should be a logical extension of your progress slides and reflect how you plan to solve experimental challenges, meet your scientific objectives, and produce novel, publishable results).

• Total presentation time should be about 20 min.
• The next 10 min will be dedicated to discussion, even though you can expect that some of the questions will be asked during your presentation (i.e. plan for an interactive presentation and leave room for general and specific questions at certain intervals).

• A good presentation takes some effort to prepare - here are a few important tips, and some valuable suggestions.

• If you are unclear about the fundamental hypothesis of your project, or what the broader background and motivation are, please ask me for feedback well before your scheduled presentation.

• Don't mix introduction, old results, background, new results, future plans - these are distinct sections, and all relate to your scientific hypothesis.

• Note the feedback you are getting, and correct your presentation immediately; otherwise, the same issues will surface again the next time you present.

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Topics (Web Uploads were discontinued in 2019)

2018

August 11
Leila: Enantioselective Synthesis of Oseltamivir Phosphate (Tamiflu) via the Iron-catalyzed Olefin Diazidation [view]
Manwika: Total Synthesis of Salvinorin A [view]
Austin: Breaking Amide Bonds using Nickel Catalysis [view]

June 9
Dishit: C-H Activation Enables a Concise Total Synthesis of Quinine and Analogues with Enhanced Antimalarial Activities [view]
Lauren: Direct β-Alkylation of Ketones and Aldehydes via Pd-Catalyzed Redox Cascade: [view]

May 26
Joe L: Pd/PTABS: Catalyst for Room Temperature Amination of Heteroarenes [view]
Nikhil: Radical Carbofluorination of Unactivated Alkenes with Fluoride Ions [view]
Ruiting: Quaternary Stereocentres Via an Enantioconvergent Catalytic SN1 Reaction [view]

May 12
Steph: Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors [view]
Evan: Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8 [view]

April 14
Leila: Enantioselective Desymmetrization of Cyclobutanones Enabled by Synergistic Palladium/Enamine Catalysis [view]
Prasanth: Total Synthesis of Astellatol [view]
Ettore: Divergent Total Syntheses of Enmein- Type Natural Products: (–)-Enmein, (–)- Isodocarpin, and (–)-Sculponin R [view]

March 17
John M: Palladium-Catalyzed Electrophilic Aromatic C–H Fluorination [view]
Austin: The Story of the Clavilactones [view]

February 17
Dishit: Total Synthesis of the Caged Indole Alkaloid Arboridinine Enabled by aza-Prins and Metal-Mediated Cyclizations [view]
Serene: Ru(II)-Catalyzed Cross-Coupling of Cyclopropenes with Diazo Compounds: Formation of Olefins from Two Different Carbene Precursors [view]
Shikha: Late-Stage Microsomal Oxidation Reduces Drug−Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189 [view]

January 24
Liming: Total Synthesis of the Caged Indole Alkaloid Arboridinine Enabled by aza-Prins and Metal-Mediated Cyclizations [view]
Ruiting: Total Synthesis of (+)-Pleuromutilin [view]
Mike F: Synthesis of α-Chiral Ketones and Chiral Alkanes Using Radical Polar Crossover Reactions of Vinyl Boron-Ate Complexes [view]

2017

December 16
Steph: Total Syntheses of (–)-Majucin and (–)-Jiadifenoxolane A, Complex Majucin-Type Illicium Sesquiterpenes [view]
Keita: Cation Radical Accelerated Nucleophilic Aromatic Substitution via Organic Photoredox Catalysis [view]

November 18
Prasanth: Total Syntheses of Disorazoles A1 and B1 and Full Structural Elucidation of Disorazole B1 [view]
Evan: Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation [view]
Austin: PGM-Catalyzed Cyclization Reactions for the Synthesis of Ergot Alkaloids [view]

October 28
Leila: Direct Synthesis of Amides by Dehydrogenative Coupling of Amines with either Alcohols or Esters: Manganese Pincer Complex as Catalyst [view]
Ruyin: Predicting a Drug's Membrane Permeability: A Computational Model Validated With in Vitro Permeability Assay Data [view]
John: Through-Space Activation Can Override Substituent Effects in Electrophilic Aromatic Substitution [view]

September 2
Dishit: Catalytic Reductive Vinylidene Transfer Reactions [view]
Shikha: Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane [view]
Serene: Parameterization of Phosphine Ligands Demonstrates Enhancement of Nickel Catalysis via Remote Steric Effects [view]

August 5
Joe: Total Synthesis of (+)-Dendrowardol C [view]
Celeste: Evaluation of Oxetan-3-Ol, Thietan-3-Ol, and Derivatives Thereof as Bioisosteres of the Carboxylic Acid Functional Group [view]
Chaemin: Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase Inhibitor [view]
Ruiting: A Concise Enantioselective Total Synthesis of (-)-Virosaine A [view]

July 22
Keita: A Modular and Enantioselective Synthesis of the Pleuromutilin Antibiotics [view]
Joel: Novel OLEDs from Emissive Photopatterned Polymer Brushes [view]
Steph: Asymmetric Radical Bicyclization of Allyl Azidoformates via Cobalt(II)-Based Metalloradical Catalysis [view]

June 24
Mike: Brook Rearrangement as Trigger for Carbene Generation: Synthesis of Stereodefined and Fully Substituted Cyclobutenes [view]
Austin: Synthesis of the Securinega Alkaloids. An Accelerated Intermolecular Rauhut−Currier Reaction Enables the Total Synthesis of (−)-Flueggenine C [view]
Evan: A Concise, Efficient, and Scalable Total Synthesis of Thapsigargin and Nortrilobolide from (R)-(-)-Carvone [view]

June 10
John: Enantioselective Total Synthesis of (+)-Wortmannin [view]
Leila: Batch and Continuous Flow One-Pot Processes using Amine Diazotization to Produce Silylated Diazo Reagents [view]
Serene: Pd(II)-Catalyzed Enantioselective C(sp3)-H Borylation [view]
Ruyin: Structural Basis for Selectivity and Diversity in Angiotensin II Receptors [view]

May 6
Tim: Unified Biomimetic Assembly of Voacalgine A and Bipleiophylline via Divergent Oxidative Couplings [view]
Dishit: Highly Diastereo- and Enantioselective Synthesis of Trifluoromethyl-Substituted Cyclopropanes via Myoglobin-Catalyzed Transfer of Trifluoromethylcarbene [view]
Chaemin: Design and Synthesis of Mercaptoacetamides as Potent, Selective, and Brain Permeable Histone Deacetylase 6 Inhibitors [view]
Liming: Total Syntheses of Highly Oxidized ent-Kaurenoids Pharicin A, Pharicinin B, 7-O-Acetylpseurata C, and Pseurata C: A [5+2] Cascade Approach [ view]

April 15
Mike: Arylation of Hydrocarbons Enabled by Organosilicon Reagents and Weakly Coordinating Anions [view]
Celeste: Investigation of a Bicyclo[1.1.1]Pentane as a Phenyl Replacement Within an LPPLA2 Inhibitor [view]
Ruiting: Stereocontrolled Synthesis of Kalihinol C [view]

March 4
Keita: Stereocontrolled Total Synthesis of (-)-Stemaphylline [view]
Steph: Aldehydes as Alkyl Carbanion Equivalents for Additions to Carbonyl Compounds [view]
Joel: Organocatalytic Stereoselective [8+2] and [6+4] Cycloadditions [view]

February 11
James: Asymmetric Palladium-Catalyzed Alkene Carboamination Reactions for the Synthesis of Cyclic Sulfamides [view]
Evan: PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models [view]
Joe: Electrocatalytic Synthesis of Ammonia at Room Temperature and Atmospheric Pressure from Water and Nitrogen on a Carbon-Nanotube-Based Electrocatalyst [view]

January 21
Liming: Assembly of the Limonoid Architecture by a Divergent Approach: Total Synthesis of (±)-Andirolide N via (±)-8-alpha-Hydroxycarapin [view]
John: Photoredox Activation of CO2 for Amino Acid Synthesis in Continuous Flow [view]
Leila: Copper-Catalyzed Bromination of C(sp3)-H Bonds Distal to Functional Groups [view]

2016

December 24
Steph: Asymmetric Synthesis of Batrachotoxin: Enantiomeric Toxins Show Functional Divergence Against NaV [view]
Mike H: Chemical Synthesis and Self-Assembly of a Ladderane Phospholipid [view]
Tanja: A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models [view]

November 19
Chaemin: Dual Inhibition of PDK1 and Aurora Kinase A: An Effective Strategy to Induce Differentiation and Apoptosis of Human Glioblastoma Multiforme Stem Cells [view]
Mike: Direct Conversion of Nitriles into Alkene Isonitriles [view]
Ruiting: Concise Total Syntheses of (+)-Haplocidine and (+)-Haplocine Via Late-Stage Oxidation of (+)-Fendleridine Derivatives [view]

October 15
Alex C.: A New Platform for the Discovery of New Macroclide Antibiotics [view]
Keita: C−H Functionalization at Sterically Congested Positions by the Platinum-Catalyzed Borylation of Arenes [view]
Serene: Enantioselective Pd-Catalyzed Allylic Alkylation Reactions of Dihydropyrido[1,2-a]indolone Substrates: Efficient Syntheses of (-)-Goniomitine, (+)-Aspidospermidine, and (-)-Quebrachamine [view]

September 10
Joe: Ligand-Accelerated Enantioselective Methylene C(sp3)-H bond activation [view]
James: Design and Synthesis of Novel Bicalutamide and Enzalutamide Derivatives as Antiproliferative Agents for the Treatment of Prostate Cancer [view]
Marina: Blurring the Role of Oligonucleotides: Spherical Nucleic Acids as a Drug Delivery Vehicle [view]
Celeste: Diversity-Oriented Synthesis Yields Novel Multistage Antimalarial Inhibitors [view]

August 6
John: 11-Step Total Synthesis of (–)-Maoecrystal V [view]
Leila: Diverse N-Heterocyclic Ring Systems via Aza-Heck Cyclizations of N-(Pentafluorobenzoyloxy)sulfonamides [view]
Evan: Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor [view]

July 9
Chaemin: Conformational Adaption May Explain the Slow Dissociation Kinetics of Roniciclib (BAY 1000394), a Type I CDK Inhibitor with Kinetic Selectivity for CDK2 and CDK9 [view]
Tanja: Discovery and Characterization of BMN673 (Talazoparib), a Novel, Highly Potent, and Orally Efficacious Poly(ADP-ribose) Polymerase-1,2 Inhibitor, as an Anticancer Agent [view]
Mike H.: Validating Eaton’s Hypothesis: Cubane as a Benzene Bioisostere? [view]

June 19
Ruiting: Enantioselective Synthesis Of An Ophiobolin Sesterterpene Via A Programmed Radical Cascade [view]
Serene: A Syn-Selective Aza-Aldol Reaction Of Boron Aza-Enolates Generated From N-Sulfonyl-1,2,-3-Triazoles And 9-BBN-H [view]
Mike: KOtBu: A Privileged Reagent for Electron Transfer Reactions? [view]

May 21
Alex: Analysis of Nanoparticle Delivery to Tumours [view]
Keita: Catalytic Enantioselective Dihalogenation and the Selective Synthesis of (−)-Deschloromytilipin A and (−)-Danicalipin A [view]
Steph: Expedient Synthesis of (+)-Lycopalhine A [view]

April 9
Evan: Nineteen-step Total Synthesis of (+) - Phorbol [view]
James: Enantioselective Synthesis of Chiral Piperidines via the Stepwise Dearomatization/Borylation of Pyridines [view]
Joe: Expanding the Strained Alkyne Toolbox [view]

March 12
Chaemin: Cell-Penetrating, Guanidinium-Rich Oligophosphoesters: Effective and Versatile Molecular Transporters for Drug and Probe Delivery [view]
Liming: Catalytic Asymmetric Total Synthesis of (−)-Actinophyllic Acid [view]
Celeste: The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat [view]

February 13
John: Strain-Release Amination [view]
Mike H: Enantioselective Total Synthesis of Akuammiline Alkaloids (+)-Strictamine, (–)-2(S)-Cathafoline, and (–)- Aspidophylline A [view]
Marina: 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors [view]

January 16
Celeste: Design of Selective PAK1 Inhibitor G-5555 [view]
Mike: Catalytic Conjunctive Cross-Coupling enabled by Metal-Induced Metallate Rearrangement [view]
Ruiting: Total Synthesis of Gelsenicine via a Catalyzed Cycloisomerization Strategy [view]

2015

December 19
Tanja: Enhanced NIR Radiation-Triggered Hyperthermia By Mitochondrial Targeting [view]
John: Catalytic [2+2+1] Synthesis Of Pyrroles From Alkynes And Diazines Via Ti(II)/Ti(IV) Redox Catalysis [view]
Steph: A Manganese Catalyst for Highly Reactive yet Chemoselective Intramolecular C(sp3)-H Amination [view]

November 21
Evan: An Eight-Step Synthesis of Epicolactone Reveals its Biosynthetic Origin [view]
Joe: Nickel-Catalyzed Suzuki-Miyaura Coupling of Amides [view]
James: Protecting-Group-Free Enantioselective Synthesis of (-)- Pallavicinin and (+)-Neopallavicinin [view]

October 24
Liming: Total Synthesis of Epoxyeujindole A [view]
Alex: Site-Selective Arene C-H Amination via Photoredoxcatalysis [view]

September 26
Raffaele: O–H Hydrogen Bonding Promotes H-Atom Transfer from α C–H Bonds for C-Alkylation of Alcohols [view]
Chaemin: Design of HIV-1 Protease Inhibitors with Amino-bis-tetrahydrofuran Derivatives as P2-Ligands to Enhance Backbone-Binding Interactions: Synthesis, Biological Evaluation, and Protein-Ligand X-ray Studies [view]
Marina: Expanded Porphyrin-Anion Supramolecular Assemblies [view]

August 8
Tanja: (-)-Meptazinol-Melatonin Hybrids as Novel Dual Inhibitors of Cholinesterases and Amyloid-β Aggregation with High Antioxidant Potency for Alzheimer’s Therapy [view]
Ruiting: Palladium-Catalyzed Decarbonylative Dehydration for the Synthesis of α-Vinyl Carbonyl Compounds and Total Synthesis of (−)-Aspewentins A, B, and C [view]
Celeste: Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2 [view]

July 25
Mike: Synergistic Gold and Iron Dual Catalysis: Preferred Radical Addition Toward Vinyl-Gold Intermediate Over Alkene [view]
John: Catalytic Asymmetric Hydroamination of Unactivated Internal Olefins [view]
Evan: Total Synthesis of Gelsemoxonine through a Spirocyclopropane Isoxazolidine Ring Contraction [view]

June 27
Joe: Stereoselective Synthesis of Chiral b-Fluoro α-Amino Acids via Pd(II)-Catalyzed Fluorination of Unactivated Methylene C(sp3)−H Bonds: Scope and Mechanistic Studies [view]
James: Chloroform as a Carbon Monoxide Precursor: In or Ex Situ Generation of CO for Pd-Catalyzed Aminocarbonylations [view]
Steph: Discovery and Reconstitution of the Cycloclavine Biosynthetic Pathway Enzymatic Formation of a Cyclopropyl Group [view]

May 30
Alex: Practical Olefin Hydroamination with Nitroarenes [view]
Zhizhou: Manganese-Catalyzed Late-Stage Aliphatic C−H Azidation [view]
Lalith: Catalytic Asymmetric Total Syntheses of (-)-Galanthamine and (-)-Lycoramine [view]
Liming: Total Synthesis and Structural Revision of (+)-Muironolide A [view]

May 1
Mike: Modular C-H Functionalization Cascade of Aryl Iodides [view]
Chaemin: Nanomolar Inhibitors of the Transcription Factor STAT5b with High Selectivity over STAT5a [view]
Marina: β-Cyclodextrin-threaded Biocleavable Polyrotaxanes Ameliorate Impaired Autophagic Flux in Niemann-Pick Type C Disease [view]

March 28
Raffaele: Ligand-Enabled meta-C–H Activation using a Transient Mediator [view]
Tanja: A New Method for the Preparation of Non-Terminal Alkynes: Application to the Total Synthesis of Tulearin A and C [view]
Ruiting: The Daphniphyllum Alkaloids: Total Synthesis of (−)-Calyciphylline N [view]

February 28
Alex: Bioorthogonal Prodrug Activation Driven by a Strain-Promoted 1,3-Dipolar Cycloaddition [view]
Celeste: Necroptosis-Inducing Rhenium(V) Oxo Complexes [view]
John: Palladium(II)-Catalyzed Enantioselective C-H Arylation of Cyclopropylmethylamines [view]

January 31
James: Rhodium-Catalyzed Borylation of Aryl 2-Pyridyl Ethers through Cleavage of the Carbon–Oxygen Bond: Borylative Removal of the Directing Group [view]
Yongzhao: Catalytic Sterepspecific syn-Dichlorination of Alkenes [view]
Joe: Pd-Catalyzed Intramolecular C-N Bond Cleavage, 1,4-Migration, sp3 C-H Activation, and Heck Reaction: Four Controllable Diverse Pathways Depending on the Judicious Choice of the Base and Ligand [view]

January 3
Liming: Total Synthesis of Rubriflordilactone A [view]
Lalith: Tuning Reactivity and Site Selectivity of Simple Arenes in C-H Activation: Ortho-Arylation of Anisoles via Arene-Metal p-Complexation [view]
Zhizhou: Pseudopterosin Synthesis from a Chiral Cross-conjugated Hydrocarbon through a Series of Cycloadditions [view]

2014

December 6
Raffaele: Catalytic Z-Selective Cross-Metathesis in Complex Molecule Synthesis: A Convergent Stereoselective Route to Disorazole C1 [view]
Chaemin: Promiscuity and Selectivity in Covalent Enzyme Inhibition: A Systematic Study of Electrophilic Fragments [view]
Marina: Small Molecule Antibacterial Peptoid Mimics: The Simpler the Better! [view]

November 8
Tanja: Total Synthesis of (-)-N-Methylwelwitindolinone B Isothiocyanate via a Chlorinative Oxabicycle Ring-Opening Strategy [view]
Nic: A Cascade Strategy Enables a Total Synthesis of (-)-Gephyrotoxin [view]
Ruiting: Total Synthesis of the Tetracyclic Antimalarial Alkaloid (±)-Myrioneurinol [view]
Mike: Total Synthesis of Gracilioether F: Development and Application of Lewis Acid Promoted Ketene-Alkene [2+2] Cycloadditions and Late Stage C-H Oxidation [view]

October 11
Alex: An Interrupted Vinylogous Iso-Nazarov Reaction: Cycloisomerization of Conjugated Trienones to Cyclopenta[b]furan Derivatives [view]
Celeste: Direct Synthesis of Diverse 2-Aminobenzo[b]thiophenes via Palladium-Catalyzed Carbon-Sulfur Bond Formation Using Na2S2O3 as the Sulfur Source [view]
John: A Unified Approach to Lycopodium Alkaloids [view]

September 6
James: A Palladium-Catalyzed Three-Component-Coupling Strategy for the Differential Vicinal Diarylation of Terminal 1,3-Dienes [view]
Yongzhao: An Efficient Strategy Single-Electron-Transfer-Induced Tandem Anion–Radical Reactions [view]
Joe: Palladium-Catalyzed Condensation of N-Aryl Imines and Alkynylbenziodoxolones to Form Multisubstituted Furans [view]

July 5
Liming: Total Synthesis of Taiwaniadducts B, C, and D [view]
Nic: Redox-Triggered C-C Coupling of Alcohols and Vinyl Epoxides [view]
Zhizhou: Air- and Water-Tolerant Rare Earth Guanidinium BINOLate Complexes as Practical Precatalysts in Multifunctional Asymmetric Catalysis [view]

June 7
Ruiting: Total Synthesis of (−)-Lepenine [view]
Raffaele: Total Synthesis of Jiadifenolide [view]
Evan: Therapeutic Targeting of Oncogenic K-Ras by a Covalent Catalytic Site Inhibitor [view]
Tanja: Rhodium(II)-Catalysed Intramolecular Annulation of 1-Sulfonyl-1,2,3-Triazoles with Pyrrole and Indole Rings: Facile Synthesis of N-Bridgehead Azepine Skeletons [view]

May 10
Eakkaphon: Phosphine-Catalyzed Enantioselective γ-Addition of 3-Substituted Oxindoles to 2,3-Butadienoates and 2-Butynoates: Use of Prochiral Nucleophiles [view]
Yongzhao: Iridium-Catalyzed Regioselective Silylation of Secondary Alkyl C−H Bonds for the Synthesis of 1,3-Diols [view]
Alex: anti-Markovnikov Hydroamination of Alkenes Catalyzed by a Two-Component Organic Photoredox System: Direct Access to Phenethylamine Derivatives [view]

April 12
Nic: Four Step Synthesis of the Antimalarial Cardamom Peroxide via an Oxygen Stitching Strategy [view]
John: C-H Methylation of Heteroarenes inspired by radical SAM Transferase [view]
Celeste: Structure-guided Rescaffolding of Selective Antagonists of Bcl-XL [view]
Mike: Decarboxylative Arylation of alpha-Amino Acids via Photoredox Catalysis [view]

March 15
James: SnAP Reagents for the One-Step Synthesis of Medium-Ring Saturated N-Heterocycles from Aldehydes [view]
Seb: Ruthenium-Catalyzed Cascade C-H Functionalization of Phenylacetophenones [view]
Joe: Total Syntheses of (–)-Kopsifoline D and (–)-Deoxoapodine: Divergent Total Synthesis via Late- Stage Key Strategic Bond Formation [view]

February 15
Feng: Total Synthesis of (±)-Distomadines A and B [view]
Steph: Simple, Chemoselective Hydrogenation with Thermodynamic Stereocontrol [view]
Liming: Total Synthesis of (±)-Lundurine B [view]

January 18
Gilmar: Catalyst-Controlled Wacker-Type Oxidation: Facile Access to Functionalized Aldehydes [view]
Josh: Direct Stereospecific Synthesis of Unprotected N-H and N-Me Aziridines from Olefins [view]
Evan: Selective Aurora Kinase Inhibitors Identified Using a Taxol-Induced Checkpoint Sensitivity Screen [view]
Raffaele: Asymmetric Synthesis from Terminal Alkenes by Cascades of Diboration and Cross-Coupling [view]

2013

December 7
Joe: Gold(I)-Catalyzed endo-Selective Intramolecular α-Alkenylation of β-Yne-Furans: Synthesis of Seven- Membered-Ring-Fused Furans and DFT Calculations [view]
Eakkaphon: Rhodium(III)-Catalyzed Azidation and Nitration of Arenes by C-H Activation [view]
Yongzhao: Total Synthesis of Gephyrotoxin by Amide-Selective Reductive Nucleophilic Addition [view]

November 9
Nic: One-Pot Zinc-Promoted Asymmetric Alkynylation/Brook-Type Rearrangement/Ene-Allene Cyclization: Highly Selective Formation of Three New Bonds and Two Stereocenters in Acyclic Systems [view]
Celeste: A New Strategy To Improve The Metabolic Stability Of Lactone [view]
Mike: Cu(OTf)2-Mediated Fluorination of Aryltrifluoroborates with Potassium Fluoride [view]
John: Catalyst-Controlled Aliphatic C-H oxidation: Prediction and Experiment [view]

October 12
James: Conversion of Azides into Diazo Compounds in Water [view]
Layal: Polypharmacology − Foe or Friend? [view]
Alex: Exploring Natural Product Chemistry and Biology with Multicomponent Reactions. 5. Discovery of a Novel Tubulin-Targeting Scaffold Derived from the Rigidin Family of Marine Alkaloids [view]
Vsevolod: Diaminophosphine Oxide Ligand Enabled Asymmetric Nickel-Catalyzed Hydrocarbamoylations of Alkenes [view]

September 21
Steph: Dearomatizing Conjugate Addition to Quinolinyl Amidines for the Synthesis of Dehaloperophoramidine through Tandem Arylation and Allylation [view]
Mustafa: Total Synthesis of Ecteinascidin 743 [view]
Liming: A Concise Total Synthesis of (+)-Scholarisine A Empowered by a Unique C−H Arylation [view]
Feng: Total Synthesis of Amphidinolide F [view]

August 24
Kara: A Unified Strategy to ent-Kauranoid Natural Products:  Total Syntheses of (–)-Trichorabdal A and (–)-Longikaurin E [view]
Gilmar: Total Synthesis of the Daphniphyllum Alkaloid Daphenylline [view]
Raffaele: A 14-Step Synthesis of (+)-Ingenol from (+)-3-Carene [view]
Evan: Radical-Based Regioselective C-H Functionalization of Electron-Deficient Heteroarenes: Scope, Tunability, and Predictability [view]

July 13
Josh: Pd-Catalyzed Chemoselective Catellani ortho-Arylation of Iodopyrroles: Rapid Total Synthesis of Rhazinal [view]
Yongzhao: Organocatalytic Oxyamination of Azlactones: Kinetic Resolution of Oxaziridines and Asymmetric Synthesis of Oxazolin-4-ones [view]
Alex: A Small Molecule Bidentate-Binding Dual Inhibitor Probe of the LRRK2 and JNK Kinases [view]
Kyu Ok: Enantio- and Diastereodivergent Dual Catalysis: α-Allylation of Branched Aldehydes [view]

June 8
Celeste: Preliminary Structure-Activity Relationships and Biological Evaluation of Novel Antitubercular Indolecarboxamide Derivatives Against Drug-Susceptible and Drug-Resistant Mycobacterium tuberculosis Strains [view]
John: Asymmetric Total Synthesis of Transtaganolides A-D and Biosynthetic Implications [view]
Nic: Total Synthesis of the Tubulin Inhibitor WF-1360F Based on Macrocycle Formation through Ring-Closing Alkyne Metathesis [view]
Mike: Iridium-Catalyzed Borylation of Secondary Benzylic C-H Bonds Directed by a Hydrosilane [view]

May 18
Layal: Privileged Scaffolds or Promiscuous Binders: A Glance of Pyrrolo[2,1-f][1,2,4]triazines and Related Bridgehead Nitrogen Heterocycles in Medicinal Chemistry [view]
James: Cu-Catalyzed Synthesis of Diaryl Thioethers and S-Cycles by reaction of Aryl Iodides with Carbon Disulfide in the Presence of DBU [view]
Joe: Nine-Step Enantioselective Total Synthesis of (-)-Vincorine [view]
Fangfei: Fragment-based Drug Design and Identification Of HJC0123, a Novel Orally Bioavailable STAT3 Inhibitor For Cancer Therapy [view]

April 20
Mustafa: Total Synthesis and Determination of the Absolute Configuration of 5,6-Dihydro-α-pyrone Natural Product Synargentolide B [view]
Atefeh: Catalyzed Nitrogenation of Alkynes: A Direct Approach to Nitriles through CΞC Bond Cleavage [view]
Steph : New Mechanistic Insight into the Copper(I)-Catalysed Azide-Alkyne Cycloaddition [view]
Feng: Syntheses of Xanthofulvin and Vinaxanthone, Natural Products Enabling Spinal Cord Regeneration [view]
Liming: Asymmetric Total Synthesis of (−)-Amphidinolide V through Effective Combinations of Catalytic Transformations [view]

March 23
Josh: A New Strategy for Efficient Synthesis of Medium and Large Ring Lactones without High Dilution or Slow Addition [view]
Brandon: Total Synthesis of Cyanolide A in the Absence of Protecting Groups, Chiral Auxiliaries, or Premetalated Carbon Nucleophiles [view]
Raffaele: A Ring-Distortion Strategy to Construct Stereochemically Complex and Structurally Diverse Compounds from Natural Products [view]

February 23
Kara: Late-Stage Deoxyfluorination of Alcohols with PhenoFluor [view]
Kyu Ok: Total Syntheses of Lyconadins A–C [view]
Alex: Systematic Exploration of Dual-Acting Modulators from a Combined Medicinal Chemistry and Biology Perspective [view]
Yongzhao: Total Synthesis of (-)-Flueggine A and (+)-Virosaine B [view]

January 12
Ben: Enantioselective Total Synthesis of Hyperforin [view]
Zhuzhu: Total Synthesis of (-)-Acetylaronotin [view]
Celeste: Assessing the Target Differentiation Potential of Imidazole-Based Protein Kinase Inhibitors [view]

2012

December 1
Jie: Total Synthesis and Stereochemical Revision of the Chlorinated Sesquiterpene (±)-Gomerone C [view]
Jaideep: Boroalkyl Group Migration Provides a Versatile Entry into α-Aminoboronic Acid Derivatives [view]
James Johnson: Rewiring Chemistry: Algorithmic Discovery and Experimental Validation of One-Pot Reactions in the Network of Organic Chemistry [view]
Jared: Total Synthesis and Biological Evaluation of Phidianidines A and B Uncovers Unique Pharmacological Profiles at CNS Targets [view]

November 3
Liming: Total Synthesis of (±)-Communesin F via a Cycloaddition with Indol-2-one [view]
Benjamin: Synthesis of THP Segments of Phorboxazoles by Michael Additions [view]
Feng: Total Synthesis and Biological Activity of the Proposed Structure of Phaeosphaeride A [view]
Mustafa: Total Synthesis of Manzamine A and Related Alkoloids [view]

October 6
Kara: Synthesis of Alkaloid (−)-205B via Stereoselective Reductive Cross-Coupling and Intramolecular [3+2] Cycloaddition [view]
Josh: Transition-Metal-Free Oxyarylation of Alkenes with Aryl Diazonium Salts and TEMPONa [view]
James JJ: (Almost) Everything You Always Wanted to Know About Cancer Stem Cells....
Brandon: A Concise Synthesis of (+)-Artemisinin [view]

August 25
Ben: Bioinspired Total Synthesis of Agelastatin A [view]
Atefeh: Guided Desaturation of Unactivated Aliphatics [view]
Chris: Stereocontrolled Organocatalytic Synthesis of Prostaglandin PGF2α in Seven Steps [view]
Dimas: Enantioselective Total Synthesis of Amphidinolide F [view]
Eric: Total Synthesis of (-)-Isoschizogamine [view]

July 28
Melissa: Rhodium(III)-Catalyzed Dehydrogenative Heck Reaction of Salicylaldehydes [view]
Celeste: A New Class Of Highly Potent And Selective Endomorphin-1 Analogues Containing Α-methylene-β-aminopropanoic Acids (Map) [view]
Zhuzhu: Protecting Group-Free Total Synthesis of (-)-Lannotinidine B [view]

June 9
Elisa: A New Stereocontrolled Synthetic Route to (−)-Echinosporin from D-Glucose via Padwa Allenylsulfone [3+2]-Anionic Cycloadditive Elimination [view]
Jie: Total Synthesis and Stereochemical Reassignment of (±)-Indoxamycin B [view]
Jaideep: Total Synthesis of Chelidonine and Norchelidonine via An Enamide-Benzyne-[2+2] Cycloaddition Cascade [view]
Jared: Scalable Total Synthesis of ( -)-Berkelic Acid by Using a Protecting- Group-Free Strategy [view]
James: The Flight of the (+)-Dactylolide: N-Heterocyclic Carbene Catalyzed Oxidative Macrolactonization: Total Synthesis of (+)-Dactylolide [view]

May 12
Feng: CRTH2 Antagonist MK-7246: A Synthetic Evolution from Discovery through Development [view]
Liming: Enantioselective Total Synthesis and Absolute Configuration of Apiosporic Acid [view]
Mustafa: Total Syntheses of Anominine and Tubingensin A [view]

April 28
Brandon: Total Synthesis of RNA Polymerase Inhibitor Ripostatin B [view]
Yongzhao: Total Synthesis of Loline Alkaloids [view]
Chris: Total Syntheses of Anominine and Tubingensin A [view]

March 31
Dimas: Total Synthesis of (-)-Anisatin [view]
Kara: Total Synthesis of (–)-Dendrobine [view]
Eric: Synthetic (±)-Axinellamines Deficient in Halogen [view]

February 18
Filip: Total Synthesis of (+)-Scholarisine A [view]
Melissa: Phosphorothioic Acids and Related Compounds as Surrogates for H2S Synthesis of Chiral Tetrahydrothiophenes [view]
Zhuzhu: Intraoperative Tumor-Specific Fluorescence Imaging in Ovarian Cancer by Folate Receptor-α Targeting: First in-human Results [view]
Yongzhao: Total Synthesis of (−)-Fusarisetin A [view]

January 7
Jared: Total Synthesis and Structural Revision of the Piperarborenines via Sequential Cyclobutane C-H Arylation [view]
Jie: Total Synthesis of Hapalindoles J and U [view]
Elisa: Dioxindole in Asymmetric Catalytic Systems: Routes to Enantioenriched 3 Substituted 3-Hydroxyoxindoles and the Preparation of Maremycin A [view]

2011

November 26
Igor: Gateway Synthesis of Daphnane Congeners and their Protein Kinase C Affinities and Cell-Growth Activities [view]
Ben: Concise, Stereocontrolled Synthesis of Citrinadin B [view]
Liming: Total Synthesis of (+)-Yohimbine via an Enantioselective Organocatalytic Pictet–Spengler Reaction [view]

November 12
Chris: Enantioselective Total Synthesis of (-)-Acetylaranotin, a Dihydrooxepine Epidithiodiketopiperazine [view]
James JJ: Emerging Drugs to Treat HNSCC: Sensitization of HNSCC to Cisplatin Through the Use of a Novel Curcumin Analog [view]
Ki Bum: Total Synthesis of (+)-Daphmanidin E [view]
Brandon: Total Synthesis of Gelsemoxonine [view]

October 8
Dimas: Total Synthesis of Oxazolomycin [view]
Kara: Total Synthesis of (+)-Decursivine [view]
Eric: Convergent Total Synthesis of (+)-Ophiobolin A [view]
Juraj: Identification of an Unexpected 2-Oxonia[3,3]sigmatropic Rearrangement/Aldol Pathway in the Formation of Oxacyclic Rings. Total Synthesis of (+)-Aspergillin PZ [view]

September 3
Zhuzhu: Selective Killing of Cancer Cells by a Small Molecule Targeting the Stress Response to ROS [view]
Filip: Scalable, Stereocontrolled Total Synthesis of (±)-Axinellamines A and B [view]
Melissa: Total Synthesis of Bryostatin 7 via C−C-Bond-Forming Hydrogenation [view]
Yongzhao: Total Synthesis of (+)-Omphadiol [view]

August 6
Jared: Total Syntheses of Heimiol A, Hopeahainol D, and Constrained Analogues [view]
Jie: Dead Ends and Detours [view]
Nate: Collective Synthesis of Natural Products by Means of Organocascade Catalysis [view]

May 21
Igor: Synthesis of the Stenine Ring System from Pyrrole [view]
Liming: Total Synthesis of (±)-Aspidophylline A [view]
Ben: Total Synthesis of (-)-Conophylline and (-)-Conophyllidine [view]
Brandon: Asymmetric [C+NC+CC] Coupling Entry to the Naphthyridinomycin Natural Product Family: Formal Total Synthesis of Cyanocycline A and Bioxalomycin β2 [view]

May 21
Chris: Total Synthesis of Epicoccin G [view]
Ki Bum: Toward More "Ideal" Polyketide Natural Product Synthesis: A Step-Economical Synthesis of Zincophorin Methyl Ester [view]
Juraj: Asymmetric Total Synthesis of (-)-Scabronine G via Intramolecular Double Michael Reaction and Prins Cyclization [view]
John: Synthesis of (-)-Okilactomycin by a Prins-Type Fragment-Assembly Strategy [view]

April 9
Eric: Total Synthesis of (±)-Alopecuridine and Its Biomimetic Transformation into (±)-Sieboldine A [view]
David: Total Synthesis of N-Methylwelwitindolinone D Isonitrile [view]
Sarang: Enantioselective Total Synthesis of (-) Jiadifenolide [view]

February 26
Melissa: 11-Step Enantioselective Synthesis of (−)-Lomaiviticin Aglycon [view]
Filip: Formal Asymmetric Synthesis of Echinopine A and B [view]
Yongzhao: Asymmetric Total Synthesis of (+)-Danicalipin A [view]
Nolan: Rapid Total Syntheses Utilizing "Supersilyl" Chemistry [view]

January 29
Marija: Concise Total Synthesis of Variocolortides A and B through an Unusual Hetero-Diels-Alder Reaction [view]
Jie: Formal Syntheses of (-)- and (+)-Phalarine [view]
Jared: Enantioselective Total Synthesis of (+)-Salvileucalin B [view]
Nate: The Leiodolide B Puzzle [view]

2010

December 4
Kara: Total Syntheses of the Marine Illudalanes Alcyopterosin I, L, M, N, and C [view]
Dimas: Total Synthesis of Chivosazole F [view]
Sarang: Synthesis of Streptolydigin, a Potent Bacterial RNA Polymerase Inhibitor [view]

October 23
Chad: Total Synthesis of (-)-Nakadomarin A [view]
Jie: Galbulimima Alkaloids (-)-GB 13 and (+)-GB 16 [view]
Eric: Total Synthesis of the Proposed Structure of Briarellin J [view]
Chris: Temporary Restraints to Overcome Steric Obstacles: An Efficient Strategy for the Synthesis of Mycalamide B [view]

September 25
Nolan: Difluorobenzocycloctyne: Synthesis, Reactivity, and Stabilization by beta-Cyclodextrin [view]
Marie-Céline: Total Synthesis and Absolute Stereochemical Assignment of (–)-Communesin F [view]
Ki-Bum: Synthesis of Cortistatins A, J, K, and L [view]
Xueling: Catalytic Enantioselective Alkylative Dearomatization-Annulation: Total Synthesis and Absolute Configuration Assignment of Hyperibone K [view]

September 4
Yongzhao: Total Synthesis of (+)-Fastigiatine [view]
Melissa: Total Synthesis of Virginiamycin M2 [view]
Filip: Total Synthesis of Sporolide B and 9-epi-Sporolide B [view]
John: Room-Temperature Alternative to the Arbuzov Reaction: The Reductive Deoxygenation of Acyl Phosphonates [view]
Sammi: Asymmetric Total Synthesis of Solandelactone E: Stereocontrolled Synthesis of the 2-ene-1,4-diol Core through a Lithiation–Borylation–Allylation Sequence [view]

August 28
David: Asymmetric Total Synthesis of Cylindrocyclophanes A and F through Cyclodimerization and a Ramberg-Bäcklund Reaction [view]
Eric: Total Synthesis of Peloruside A Through Kinetic Lactonization and Relay Ring-Closing Metathesis Cyclization Reactions [view]
Marija: Total Synthesis of All (-)-Agelastatin Alkaloids [view]
Jie: Galbulimima Alkaloids (-)-GB 13 and (+)-GB 16 [view]

July 10
Kara: An Enantioselective Total Synthesis of (+)-Peloruside A [view]
Gary: Synthesis of the QRSTU Domain of Maitotoxin and Its 85-epi-and 86-epi-Diastereomers [view]
Mike: Total Synthesis of (+)-Sieboldine A [view]
Nilesh: Total Synthesis and Structural Reassignment of (+)-Dictyosphaeric Acid A: A Tandem Intramolecular Michael Addition/Alkene Migration Approach [view]

May 22
Sammi: Stereoretentive Suzuki-Miyaura Coupling of Haloallenes Enables Fully Stereocontrolled Access to (−)-Peridinin [view]
Sarang: Total Synthesis and Biological Evaluation of the Resveratrol-Derived Polyphenol Natural Products Hopeanol and Hopeahainol A [view]
Xueling: Total Synthesis of (-)-Anominine [view]
John: Scalable Total Syntheses of N-Linked Tryptamine Dimers by Direct Indole-Aniline Coupling: Psychotrimine and Kapakahines B and F [view]

April 24
Nolan: Enantioselective Synthesis of Englerins A and B [view]
Melissa: Total Synthesis of Coralloidolides A, B, C, and E [view]
Filip: Total Synthesis of (+)-Complanadine A Using an Iridium-Catalyzed Pyridine C-H Functionalization [view]
Marie-Celine: Polycavernoside A: The Prins Macrocyclization Approach [view]

March 27
Jared: Total Synthesis of Kendomycin Featuring Intramolecular Doetz Benzannulation [view]
David: [view]
Marija: Total Synthesis of the Lycorenine-Type Amaryllidaceae Alkaloid Clivonine via a Biomimetic Ring-Switch from a Lycorine-Type Progenitor [view]
Adam: Total Synthesis of Cyclosporine:Access to N-Methylated Peptides via Isonitrile Coupling Reactions [view]

March 6
Gary: Total Synthesis of Echinopines A and B [view]
Kara: Total Synthesis of (+)-Fendleridine and (+)-1-Acetylaspidoalbidine [view]
Mike: Total Synthesis of the Polycyclic Fungal Metabolite (±)-Communesin F [view]
Nilesh: Total Synthesis of Auripyrones A and B and Determination of the Absolute Configuration of Auripyrone B [view]

January 23
Chad: Total Synthesis of Palau’amine [view]
Chris: Total Synthesis of (+)-Isatisine A [view]
Junyan: Anguinomycins and Derivatives: Total Syntheses, Modeling, and Biological Evaluation of the Inhibition of Nucleocytoplasmic Transport [view]
Eric: Total Synthesis of (-)-Mersicarpine [view]

2009

December 26
Tingting: Enantioselective Synthesis of (+)-Cephalostatin 1 [view]
Filip: Chemical and Biological Studies of Nakiterpiosin and Nakiterpiosinone [view]
Rachel: Synthesis of (gamma)-Rubromycin [view]
Marija: Total Synthesis of Spirastrellolide F Methyl Ester [view]

November14
Melissa: Towards Maoecrystal V: A Comparison of Recent Strategies [view]
John: Approaches to the Core of Cortistatin A [view]
Nolan: Total Synthesis of Vinigrol [view]
Marie-Céline: Total Synthesis of (–)-Nakadomarin A [view]

October 3
Nate: Total Syntheses of Isodomoic Acids G and H [view]
Jared: Construction of Two Vicinal Quaternary Carbons by AsymmetricAllylic Alkylation: Total Synthesis of Hyperolactone C and(-)-Biyouyanagin A [view]
Adam: Total Synthesis of (–)-Himandrine [view]
David: Development of a Merged Conjugate Addition/Oxidative Coupling Sequence. Application to the Enantioselective Total Synthesis of Metacycloprodigiosin and Prodigiosin R1 [view]

September 12
Gary: Application of Cross-Conjugated Heteroaromatic Betaines to the Synthesis of the Schizozygane Alkaloid (±)-Strempeliopine [view]
Mike: Enantioselective Total Synthesis of the Marine Toxin (–)-Gymnodimine Employing a Barbier-Type Macrocyclization [view]
Kara: Nine-Step Enantioselective Total Synthesis of (+)-Minfiensine [view]
Karla: Total Synthesis and Study of 6-Deoxyerythronolide B (6-dEB) by late-stage C–H Oxidation [view]

August 15
Chad: Stereoselective Synthesis of β-Hydroxyalleneswith Multiple Contiguous Stereogenic Centers via Aldehyde Addition to α-Alkenyl-Substituted Zirconacyclopentenes [view]
Chenbo: Stereocontrolled Chlorination in Natural Product Synthesis [view]
Eric: A Catalytic, Bronsted Base Strategy for the Intermolecular Allylic C-H Amination [view]

June 20
John: Toward Palau’amine: Hg(OTf)2-Catalyzed Synthesis of the Cyclopentane Core [view]
Nate: Iridium-Catalyzed Asymmetric Isomerization of Primary Allylic Alcohols [view]
Tingting: A Stereocontrolled Total Synthesis of 4-Hydroxydictyolactone [view]
Rachel: Pd-catalyzed Highly Diastereoselective Oxidative Cascade Cyclizations [view]

May 23
Nolan: Enantioselective Synthesis of beta-Iodo Morita-Baylis-Hillman Esters by a Catalytic Asymmetric Three-Component Coupling Reaction [view]
Marie-Celine: Indoles from Simple Anilines and Alkynes: Palladium-Catalyzed C-H Activation Using Dioxygen as the Oxidant [view]
Filip: Lanthanum(III) Triflate-Catalyzed Cyclopropanation via Intramolecular Methylene Transfer [view]
Melissa: A Stereoselective Synthesis of the Bromopyrrole Natural Product (-)-Agelastatin A [view]
David: Negishi Coupling of Secondary Alkylzinc Halides with Aryl Bromides and Chlorides [view]

April 11
Adam: Gold-Catalyzed Homogeneous Oxidative Cross-Coupling Reactions [view]
Maciej: anti-Aminoallylation of Aldehydes via Ruthenium-Catalyzed Transfer Hydrogenative Coupling of Sulfonamido Allenes: 1,2-Aminoalcohols [view]
Marija: A Meta Selective Copper-Catalyzed C-H Bond Arylation [view]
Jared: Two Titanium-Catalyzed Reaction Sequences for Syntheses of Pyrroles from (E/Z)-Chloroenynes or alpha-Haloalkynols [view]
Rob: Total Synthesis of Indolizidine Alkaloid (—)-209D: Overriding Substrate Bias in the Asymmetric Rhodium-Catalyzed [2+2+2] Cycloaddition [view]

February 14
Chris: Asymmetric Synthesis of Medium-Sized Rings by Intramolecular Au(I)-Catalyzed Cyclopropanation [view]
Gary: Cross-Coupling Reactions of Aromatic and Heteroaromatic Silanolates with Aromatic and Heteroaromatic Halides [view]
Karla: Nonlinear Effects (NLE) in Asymmetric Catalysis [view]
Nora: Boron Nitride Nanotubes Are Noncytotoxic and Can Be Functionalized for Interaction with Proteins and Cells [view]

January 17
Carl: A New Efficient Catalytic System for the Chemoselective Cobalt-Catalyzed Cross-Coupling of Aryl Grignard Reagents with Primary and Secondary Alkyl Bromides [view]
Akira: N-Heterocyclization of Naphthylamines with 1,2-and 1,3-Diols Catalyzed by an Iridium Chloride/BINAP System [view]
Chenbo: Direct Cross-Coupling Reaction of Simple Alkenes with AcrylatesCatalyzed by Palladium Catalyst [view]
Eric: A Copper-Catalyzed Tandem Synthesis of Indolo- and Pyrrolo[2,1-a]isoquinolines [view]
Chad: Palladium-Catalyzed Annulation of Acyloximes with Arynes (or Alkynes): Synthesis of Phenanthridines and Isoquinolines [view]

2008

December 20
Melissa: Dicobalt Hexacarbonyl Complexes of Alkynyl Imines in a Sequential Staudinger/Pauson-Khand Process.  A Route to New Fused Tricyclic β-Lactams [view]
Kalyani: Nickel-Catalyzed Decarbonylative Addition of Anhydrides to Alkynes [view]
John: Mechanistic Studies on the Copper-Catalyzed N-Arylation of Amides [view]
Tingting: Efficient Formation of Ring Structure Utilizing Multisite Activation by Indium Catalysis [view]

October 18
Filip: Direct Catalytic Asymmetric Addition of Allylic Cyanides to Ketoimines [view]
Laurent: Pushing the Limits of the Metathesis Reaction: Design of the NHC ligand [view]
Nate: Synthesis of Cyclobutenes by Highly Selective Transition-Metal-Catalyzed Ring Expansion of Cyclopropanes [view]
Nolan: [(NHC)2Cu]X Complexes as Efficient Catalysts for Azide-Alkyne Click Chemistry at Low Catalyst Loadings [view]

September 26
Maciej: Intramolecular Arylcyanation of Alkenes [view]
Adam: Reactivity of (2-Alkenyl-3-pentene-1,5-diyl)iron Complexes: Preparation of Functionalized Vinylcyclopropanes and Cycloheptadienes [view]
Jared: Palladium-Catalyzed Intramolecular Coupling of Arenes and Unactivated Alkanes in Air [view]
Li: Intra/Intermolecular Direct Allylic Alkylation via Pd(II)-Catalyzed Allylic C-H Activation [view]
John: Efficient Iron-Catalyzed N-Arylation of Aryl Halides with Amines [view]

August 30
Gary: Palladium-Catalyzed Reactions of Arylindium Reagents Prepared Directly from Aryl Iodides and Indium Metal [view]
Nora: Sonogashira Couplings of Aryl Bromides: Room Temperature, Water Only, No Copper [view]
Rob: Intramolecular Huisgen-Type Cyclization of Platinum-Bound Pyrylium Ions with Alkenes and Subsequent Insertion into a Benzylic C-H Bond [view]
Amol: Synthesis of 1,1-Disubstituted Olefins via Catalytic Alkyne Hydrothiolation/ Kumada Cross Coupling [view]
Karla: Branched-Regioselective Hydroformylation with Catalytic Amounts of a Reversibly Bound Directing Group [view]
David: Direct and Selective Arylation of Tertiary Silanes with Rhodium Catalyst [view]

July 19
Marija: Construction of Aryliridium – Salen Complexes: Enantio- and Cis-Selective Cyclopropanation of  Conjugated and Nonconjugated Olefins [view]
Jitendra: Arylhalide-Tolerated Electrophilic Amination of Arylboronic Acids with N-Chloroamides Catalyzed by CuCl at Room Temperature [view]
Chenbo: The Total Synthesis of (-)-Cyanthiwigin F by Means of Double Catalytic Enantioselective Alkylation [view]
Eric: Pd-Catalyzed Sequential Reactions via Allene Intermediate for the Synthesis of Polycyclic Frameworks Containing 2,3-Dihydrofuran Units [view]
Chad: Water-Mediated Catalyst Preactivation: An Efficient Protocol for C-N Cross-Coupling Reaction [view]

June 28
Chris: One-Pot Synthesis of Highly Functionalized Pyridines via a Rhodium Carbenoid Induced Ring Expansion of Isoxazoles [view]
Julia: Gold(I)-Catalyzed Cycloisomerization of 1,7- and 1,8-Enynes: Application to the Synthesis of a New Allocolchicinoid [view]
Kalyani: Rhenium-Catalyzed Synthesis of Multisubstituted Aromatic Compounds via C-C Single-Bond Cleavage [view]
Akira: Catalytic Enantioselective Allyl- and Crotylboration ofAldehydes Using Chiral Diol•SnCl4 Complexes. Optimization, Substrate Scope and Mechanistic Investigations [view]
Tingting: Ruthenium-Catalyzed Azide-Alkyne Cycloaddation: Scope and Mechnism [view]
Nate: Zinc-Catalyzed Enantiospecific sp3-sp3 Cross-Coupling of alpha-Hydroxy Ester Triflates with Grignard Reagents [view]

May 31
Jennie: Copper-Catalyzed Reaction of Alkyl Halides with Cyclopentadienylmagnesium Reagent [view]
Laurent: Iron –Catalyzed Direct Arylation through Directed C-H Bond Activation [view]
Filip: Diastereoselective Nickel-Catalyzed Reductive Aldol Cyclizations Using Diethylzinc as the Stoichiometric Reductant: Scope and Mechanistic Insight [view]
David: Asymmetric Copper-Catalyzed Synthesis of alpha-Amino Boronate Esters from N-tert-Butanesulfinyl Aldimines [view]
Amir: Cancer Wars - The Metastasis Strikes Back [view]
Bryan: Highly Reactive, General and Long-Lived Catalysts for Palladium-Catalyzed Amination of Heteroaryl and Aryl Chlorides, Bromides, and Iodides: Scope and Structure-Activity Relationships [view]

April 26
Adam: Total Syntheses of Minfiensine [view]
Zhiyong: New Chemistry with Old Functional Groups: On the Reaction of Isonitriles with Carboxylic Acids-A Route to Various Amide Types [view]
Maciej: Asymmetric Synthetic Access to the Hetisine Alkaloids:Total Synthesis of (+)-Nominine [view]
Li: Site-Specific ProdrugRelease Using Visible Light [view]

March 29
Karla: A Multifaceted Phosphate Tether: Application to the C15-C30 Subunit of Dolabelides A-D [view]
David:Tandem Rh(I)-Catalyzed [(5+2)+1] Cycloaddition/Aldol Reaction for the Construction of Linear Triquinane  Skeleton:Total Syntheses of (+)-Hirsutene and (+)-1-Desoxyhypnophilin [view]
Josh: A Concise Approach to Vinigrol [view]
Melissa: Baran Lab Syntheses of the Axinellamines [view]
Abhisek: Ring Opening/Fragmentation of Dihydropyrones for the Synthesis of Homopropargyl Alcohols [view]
Rob: Powdered KOH in DMSO: An Efficient Base for Asymmetric Cyclization via Memory of Chirality at Ambient Temperature [view]

February 16
Shuli: Total Synthesis of Platencin [view]
Kalyani: Concise Total Synthesis of (+)-WIN 64821 and (-)-Ditryptophenaline [view]
Chad: A Palladium-Catalyzed Alkylation/Direct Arylation Synthesis of Nitrogen-Containing Heterocycles [view]
Marija: Synthesis of the Sporolide Ring Framework through a Cascade Sequence Involving an Intramolecular [4+2] Cycloaddition Reaction of an o-Quinone [view]
Chenbo: Alkynes as StilleReaction Pseudohalides: Gold- and Palladium-CocatalyzedSynthesis of Tri-and Tetra-Substituted Olefins [view]
Jitendra: Concise Enantioselective Total Syntheses of (+)-Homochelidonine, (+)-Chelamidine, (+)-Chelidonine, (+)-Chelamine and (+)-Norchelidonine via a Pd (II)-catalyzed Ring-Opening Strategy [view]

January 5
John: Facile preparation of alpha-amino ketones from oxidative ring-opening of aziridines by pyridine N-oxide [view]
Julia: An Efficient Synthetic Approach to Cyanocycline A and Bioxalomycin beta2 via [C+NC+CC] coupling [view]
Jennifer: Total Synthesis of (+/-)-Goniomitine via a Formal Nitrile/Donor-Acceptor Cyclopropane [3 + 2] Cyclization [view]
Masafumi: Thiol-Catalyzed Stereoselective Transfer Hydroamination of Olefins with N-Aminated Dihydropyridines [view]

2007

November 24
Filip: Asymmetric Allylboration of Acyl Imines Catalyzed by Chiral Diols [view]
Bryan: An Unexpected Organocatalytic Asymmetric Tandem Michael/Morita-Baylis-Hillman Reaction [view]
Josh: Total Synthesis of (-)-Okilactomycin [view]
Lisa: Acid Catalysed Rearrangement of Fused Alkylideneoxetanols [view]
Maciej: A Predictably Selective Aliphatic C–H Oxidation Reaction for Complex Molecule Synthesis [view]

October 27
Amir: A Minimal Peptide Sequence That Targets Fluorescent and Functional Proteins into the Mitochondrial Intermembrane Space [view]
Adam: Silenes in organic synthesis: a concise synthesis of (±)-epi-picropodophyllin [view]
David W.: Total Synthesis of Resveratrol-Based Natural Products: A ChemoselectiveSolution [view]
Melissa: Lewis Base Activation of Lewis Acids: Development of a Lewis Base Catalyzed Selenolactonization [view]
Bill: Differentiation of Nonconventional “Carbanions” – The Total Synthesis of Nemorosone and Clusianone [view]
Erikah: Total Synthesis of (-)-Sarain A [view]

September 15
Chad: Palladium-Catalyzed Synthesis of Cyclopentane-Fused Benzocyclobutenes via Tandem Directed Carbopalladation/C-H Bond Functionalization [view]
Shuli: TransannularRearrangement of Activated Lactams: Stereoselective Synthesis of Substituted Pyrrolidine-2,4-diones from Diketopiperazines [view]
Zhiyong: A Practical, Enantioselective Synthetic Route to a Key Precursor to the Tetracycline Antibiotics [view]
Chenbo: Synthesis of Azadirachtin: A Long but Successful Journey [view]
Julia: Total Synthesis of (+)-Suaveolindole [view]
Marija: Epoxide-Opening Cascades Promoted by Water [view]

August 18
Akira: Approach to the Homoerythrina Alkaloids Using a Tandem N-Alkylation/Azomethine Ylide Cycloaddition [view]
John M.: Total Synthesis of Kinamycins C, F, and J [view]
Korede: Highly Stereoselective Prins Cyclization of (Z)- and (E)-Brominated Homoallylic Alcohols to 2,4,5,6-Tetrasubstituted Tetrahydropyrans [view]
Amol: Metal-Catalyzed Regiodivergent Cyclization of gamma-Allenols: Tetrahydrofurans versus Oxepanes [view] & Lewis Acid Promoted Imine Synthesis [view]
Jennifer: Total Synthesis of Solandelactones E and F, Homoeicosanoids from the Hydroid Solanderia Secunda [view]

July 28
David A.: Enantioselective Friedel-Crafts Alkylations Catalyzed by Bis(oxazolinyl)pyridine – Scandium(III) Triflate Complexes [view]
Lisa: Synthesis of the Entire Carbon Framework of the Keracidin Chromophore Aglycon [view]
Filip: A Practical Synthesis of (-)-Oseltamivir [view]
Melissa: Construction of Tetrahydrofurans by Pd(II)/Pd(IV)-Catalyzed Aminooxygenation of Alkenes [view]
Josh: Total Synthesis, Stereochemical Reassignment, and Absolute Configuration of Chlorofusin [view]
Bryan: Copper-Catalyzed Tethered Aziridination of Unsaturated N-Tosyloxy Carbamates [view]

June 16
Zhiyong: Total Synthesis and Revised Structure of Biyouyanagin A [view]
Erikah: Enantioselective Total Synthesis of (-)-Salinosporamide A (NPI-0052) [view]
Amir: Synthesis of Nitric Oxide-Releasing Silica Nanoparticles [view]
David W.: The Catalytic Cross-Coupling of Unactivated Arenes [view]
Shuli: A Diosphenol-Based Strategy for the Total Synthesis of (-)-Terpestacin [view]
Maciej: A New Multicomponent Reaction Catalyzed by [Lewis acid]+[Co(CO)4]-Catalyst [view]

May 12
Chad: Enantioselective Synthesis of (+)-Majusculone [view]
Bill: Total Synthesis of (+)-Strychnine via a [4+2]-Cycloaddition/Rearrangement Cascade [view]
Maciej: Direct, Catalytic Hydroaminoalkylation of Unactivated Olefins with N-Alkyl Arylamines [view]
Chenbo: Chiral N-Heterocyclic Carbenes in Natural Product Synthesis: Application of Ru-Catalyzed Asymmetric Ring-Opening/Cross-Metathesis and Cu-Catalyzed Allylic Alkylation to Total Synthesis of Baconipyrone C [view]
Kalyani: Mild Cobalt-Catalyzed Hydrocyanation of Olefins with Tosyl Cyanide [view]
Marija: Gold(I)-Catalyzed Bis-Spiroketalization: Synthesis of the Trioxadispiroketal-Containing A-D Rings of Azaspiracid [view]

April 7
Adam: Sequential Silylcarbocyclization/Silicon-Based Cross-Coupling Reactions [view]
John M.: Nucleophilic Addition to a p-Benzyne Derived from an Enediyne: A New Mechanism for Halide Incorporation into Biomolecules [view]
Kalyani: Enantioselective Total Synthesis of the Osteoclastogenesis Inhibitor (+)-Symbioimine [view]
Julia: Total Syntheses of (+)-Lyconadin Aand (-)-Lyconadin B [view]
Jennifer: Unified, Radical-Based Approach for the Synthesis of Spiroketals [view]

March 3
Nilu: Total Synthesis of Jerangolid D [view]
David A.: Mild and Selective Hydrozirconation of Amides to Aldehydes Using Cp2Zr(H)Cl: Scope and Mechanistic Insight [view]
John: Effect of Substitution on the Intramolecular 1,3-Dipolar Cycloaddition of Alkene Tethered Münchnones [view]
Lisa: Cyclisation Reaction of Cyano-Substituted Unsaturated Esters Promoted By Conjugate Addition Of Organoborons [view]
Cody: Multicomponent Reactions Involving Tricyclooxonium Ylide Intermediate: Diastereoselective Synthesis of Mono- and Bisalkoxyoctahydro-1,4-benzodioxocin-6(5H)-one Frameworks [view]

February 16
Adam: Asymmetric Total Syntheses of (+)-3-(Z)-Laureatin and (+)-3-(Z)-Isolaureatin by “Lone Pair-Lone Pair Interaction-Controlled” Isomerization [view]
David W.: Biogenetic hypothesis and first steps towards a biomimetic synthesis of haouamines [view]
Erikah: Intramolecular Cyclobutadiene Cycloaddition/Cyclopropanation/Thermal Rearrangement: An Effective Strategy for the Asymmetric Syntheses of Pleocarpenene and Pleocarpenone [view]
Bryan: Highly Enantioselective Friedel-Crafts Reaction of Indoles with Imines by a Chiral Phosphoric Acid [view]
Bill: Domino Ring-Opening/Recyclization Reactions of Doubly Activated Cyclopropanes as a Strategy for the Synthesis of Furoquinoline [view]
Amir: Targeting Antioxidantsto Mitochondria [view]

January 7
Stephan:Asymmetric Synthesis of a-Substituted Allyl Boranes and TheirApplication in the Synthesis of Iso-agatharesinol [view]
Zhiyong: Catalytic Enantioselective Mannich-type Reactions of Ketoimines [view]
Shuli: A Sakurai-Prins-Ritter Sequence for the Three-Component Diastereoselective Synthesis of 4-Amino Tetrahydropyrans [view]
Chenbo: Vanadium-Catalyzed Asymmetric Epoxidation of Homoallylic Alcohols [view]
Amol: Enantioselective Total Synthesis of (+)-Homochelidonine by a PdII- Catalyzed Asymmetric Ring-Opening Reaction of a meso-Azabicyclic Alkene with an Aryl Boronic Acid [view]

2006

November 25
Kalyani: Lewis Base Activation of Grignard Reagents with N-Heterocyclic Carbenes. Cu-Free Catalytic Enantioselective Additions to γ-Chloro-α,β-Unsaturated Esters [view]
Josh: Asymmetric Total Synthesis of (+)- and ent-(-)-Yatakemycin and Duocarmycin SA: Evaluation of Yatakemycin Key Partial Structures and Its Unnatural Enantiomer [view]
Maciej: Mapping the Landscape of Potentially Primordial Informational Oligomers [view]
Jennifer: Magnesium Iodide Promoted Ring Expansion of Secondary Methylenecyclopropyl Amides [view]
Julia: Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras [view]

October 28
John: xDNA: A New Genetic System? [view]
Bryan: Total Synthesis of Antheliolide A [view]
Cody: Stereoselective Synthesis of N-Alkylaziridines from N-Chloroamines [view]
David A: Palladium-Mediated Functionalization of Heteroaromatic Cations: Comparative Study on Quinolizinium Cations [view]

September 30
Bill: Total Synthesis of (-)-Himgaline [view]
Stephan: Enantioselective Total Synthesis of Guanacastepene Using an Uncommon 7-Endo Heck Cyclization as a Pivotal Step [view]
Adam: The Hexacyclinol Incident [view]
David W: Small-Molecule Activation of Procaspase-3 to Caspase-3 as a Personalized Anticancer Strategy [view]
Nilu: Palladium-Catalyzed Alkylation of sp2 and sp3 C-H Bonds with Methylboroxine and Alkylboronic Acids: Two Distinct C-H Activation Pathways [view]

August 12
Chenbo: Pd-Catalyzed α-Arylation of Trimethylsilyl Enol Ethers with Aryl Bromides and Chlorides [view]
Erikah: Strain Release Rearrangement of N-Vinyl-2-Aziridines. Total Synthesis of the Anti-Leukemia Alkaloid (-)-Deoxyharringtonine [view]
Zhiyong: Total Synthesis of Iejimalide B [view]
Grace: Synthetic Studies on Quinine: Quinuclidine Construction via a Ketone Enolate Regio-and Diastereoselective Pd-Mediated Allylic Alkylation [view]

July 1
Kalyani: Total Synthesis and Stereochemistry of Pinnatoxins B and C [view]
Julia: Reductive Carbodiazenylation of Nonactivated Olefins via Aryl Diazonium Salts [view]
Maciej: Total Syntheses of Amphidinolide X and Y [view]
Tom: Glycerol as a Source of Fuels and Chemicals by Low-Temperature Catalytic Processing [view]
John: Highly Diastereoselective Asymmetric Mannich Reactions of 1,3-Dicarbonyls with Acyl Imines [view]

May 6
Bryan: New Synthetic Routes to Tamiflu [view]
Erick: New Methods of Indole Formations and Applications in Total Synthesis [view]
Zhenyu: Asymmetric Reduction of Oxime Ethers [view]
Dhana: Preparation of Annulated Nitrogen Containing Heterocycles via a One-Pot Palladium-Catalyzed Alkylation/Direct Arylation Sequence [view]
David: Axially Chiral Biaryl Diols Catalyze Highly Enantioselective Hetero-Diels-Alder Reactions Through Hydrogen Bonding [view]

April 1
Adam: Enantioselective Synthesis of Cyclic Enol Ethers and All-Carbon Quaternary Stereogenic Centers Through Catalytic Asymmetric Ring-Closing Metathesis [view]
Shinya: Mechanistic Implications in the Morita–Baylis–Hillman Alkylation: Isolation and Characterization of an Intermediate [view]
Erikah: A Synthesis of (+)-Saxitoxin [view]
Michel: Nickel-Catalyzed Three-Component [3+2+2] Cocyclization of Ethyl Cyclopropylideneacetate and Alkynes [view]
Juan: Total Synthesis of (±)-Haouamine A [view]
David: Rising Stars Of Synthesis: The Post-doctoral work of Scott A. Snyder [view]

March 4
Nilu: Tetraarylphosphonium Salts as Solubility-Control Groups: Phosphonium-Supported Triphenylphosphine and Azodicarboxylate Reagents [view]
Zhenglai: Asymmetric Catalysis by Chiral Hydrogen-Bond Donors [view]
Chenbo: Ladder Polyether Synthesis via Epoxide-Opening Cascades Using aDisappearing Directing Group [view]
Grace: Enantioselective Meerwein-Schmidt-Ponndorf-Verley (MSPV) Reduction of Ketimines Using 2-Propanol and (BINOL)Al III [view]
Stephan: Platinum- and Gold-Catalyzed Rearrangement Reactions of PropargylAcetates: Total Synthesis of (-)-α-Cubebene, (-)-Cubebol, Sesquicarene and related Terpenes [view]
Zhiyong: Chemoselective Amide Ligations by Decarboxylative Condensations of N-Alkylhydroxylamines and a-Ketoacids [view]

January 21
Josh: Total Synthesis of Salinosporamide A [view]
Kalyani: Bifunctional Thiourea-Catalyzed Diastereo- and Enantioselective Aza-Henry Reaction [view]
Claire: Microwave-Assisted Concise Total Syntheses of Quinazolinobenzodiazepine Alkaloids [view]
Markus: Iron in the Service of Chromium: The ortho-Benzannulation of trans,trans-Dienyl Fischer Carbene Complexes [view]
Tom: Group 4 Metals in Polyketide Synthesis: A Convergent Strategy for the Synthesis of Polypropionate-Derived (E,E)-Trisubstituted 1,3-Dienes [view]
Maciej: Recent Applications of Chiral Silicon Reagents [view]

2005

October 15
Erick: Enantioselective Organo-Cascade Catalysis [view]
Adam: Highly Enantio- and Diastereoselective One-Pot Synthesis ofAcyclic Epoxy Alcohols and Allylic Epoxy Alcohols [view]
Ruth: Group Selective Enyne RCM [view]
Anthony: Total Synthesis of (±)-Garsubellin A [view]
Dhana: Total Synthesis of (-)-SNF4435 C and (+)-SNF 4435 D [view]
Jingbo: A Diels-Alder Macrocyclization Enables an Efficient Asymmetric Synthesis of the Antibacterial Natural Product Abyssomicin C [view]

September 3
Erikah: Deoxygenation of Alcohols employing Water as the Hydrogen Atom Source [view]
David: Studies toward the Synthesis of Azadirachtin: Total Synthesis of a Fully Functionalized ABC Framework and Coupling with a Norbornene Domain [view]
Nilu: Interrupted Nazarov Cyclization on Silica Gel [view]
Shinya: Synthesis of the Tetrahydroisoquinoline Alkaloid (±)-Renieramycin G and a (±)-Lemonomycinone Analogue from a Common Intermediate [view]
Josh: Total Synthesis of Thiostrepton [view]
Bryan: Iodomethylzinc Phosphates: Powerful Reagents for the Cyclopropanation of Alkenes [view]

June 25
Grace: A Highly Efficient Organocatalyst for Direct Aldol Reactions of Ketones and Aldehydes [view]
Michel: DNA-Based Asymmetric Catalysis [view]
Mike: Stereochemical Memory Effects in Alkene Radical Cation/Anion Contact Ion Pairs: Effect of Substituents and Models for Diastereoselectivity [view]
Tyler: Total Synthesis of the Neotropical Poison-Frog Alkaloid (-)-205B [view]
Chenbo: Organophosphorus Esters of 1-Hydroxy-7-azabenzotriazole: A New Peptide Couping Reagent [view]

June 4
Claire: Spiro-Cyclopropanation from Oxoallylsilanes [view]
David: High Performance of Rh(Phebox) Catalysts in Asymmetric Reductive Aldol Reaction: High Anti-Selectivity [view]
Graciela: Molybdenum Oxides as Highly Effective Dehydrative Cyclization Catalysts for the Synthesis of Oxazolines and Thiazolines [view]
Tom: Spinosyn G: Proof of Structure by Semisynthesis [view]
Markus: Absolute Asymmetric Photocyclization of Isopropylbenzophenone Derivatives Using a Cocrystal Approach Involving Single-Crystal-to-Single-Crystal Transformation [view]
Maciej: The Tetracycline Antibiotics [view]

April 30
Erikah: Tetraorganosilicon Reagents for the Silicon-Based Cross-Coupling Reaction [view]
Jingbo: Gold-Catalyzed Assembly of Heterobicyclic Systems [view]
Anthony: A Modular Approach to Polyketide Building Blocks: Cycloadditions of Nitrile Oxides and Homoallylic Alcohols [view]
Juan: Enantioselective Synthesis of Stephacidin B [view]
Bryan: Catalytic Enantioselective Construction of All-Carbon Quaternary Stereocenters: Synthetic and Mechanistic Studies of the C-Acylation of Silyl Ketene Acetals [view]
Ruth: Total Synthesis of Antascomincin B [view]

April 2
Michel: Stereoselective Transformations of Trihalomethylcarbinols Induced by Chromous Chloride [view]
Erick: Direct C-Arylation of Free (NH)-Indoles and Pyrroles Catalyzed by Ar–Rh(III) Complexes Assembled In Situ [view]
David: The Direct Coupling Of Carbonyl Compounds With Indoles And Pyrroles [view]
Gil: Cooperative Catalysis by General Acid and Base Bifunctionalized Mesoporous Silica Nanospheres [view]
Jim: The Direct Acyl-Alkylation of Arynes [view]

February 26
Grace: Stereocontrolled Synthesis of Angularly Substituted 1-Azabicyclic Rings by Cationic 2-Aza-Cope Rearrangement [view]
Jelena: A Quantitative Cell-Based High-Content Screening Assay for the Epidermal Growth Factor Receptor-Specific Activation of Mitogen-Activated Protein Kinase [view]
Tyler: Enantioselective Direct Intermolecular Aldol Reactions with Enantiotopic Group Selectivity and Dynamic Kinetic Resolution [view]
Mike: Asymmetric Total Synthesis of (–)-Agelastatin A Using Sulfinimine (N-Sulfinyl Imine) Derived Methodologies [view]
Nilu: Dynamic Ligand Exchange of the Lanthanide Complex Leading to Structural and Functional Transformation: One Pot Sequential Catalytic Asymmetry Epoxidation-Regioselective Epoxide-Opening Process [view]

January 15
Tamara: Method for the Rapid Synthesis of Highly Functionalized 2-Hydroxy-1-naphthoates. Synthesis of the Naphthoic Acid Components of Neocarzinostatin Chromophore and N1999A2 [view]
Claire: A Fluorous-Phase Pummerer Cyclative-Capture Strategy for the Synthesis of Nitrogen Heterocycles [view]
Corey: Total Synthesis of Ingenol [view]
David: Nozaki-Hiyama-Kishi Chromium Couplings [view]
Graciela: Nickel-Catalyzed Addition of Dimethylzinc to Aldehydes across Alkynes and 1,3-Butadiene: An Efficient Four-Component Connection Reaction [view]

2004

November 27
Bryan: Regiospecific Functionalization of Methyl C-H Bonds of Allkyl Groups in Reagents with Heteroatom Functionality [view]
Ruth: Ruthenium- and Platinum-Catalyzed Sequential Reactions: Selective Synthesis of Fused Polycyclic Compounds from Propargylic Alcohols and Alkenes [view]
Tom: Meerwein-Ponndorf-Verley Alkynylation of Aldehydes: Essential Modification of Aluminum Alkoxides for Rate Acceleration and Asymmetric Synthesis [view]
Erick: Direct Oxidative Heck Cyclizations: Intramolecular Fujiwara-Moritani Arylations for the Synthesis of Functionalized Benzofurans and Dihydrobenzofurans [view]
Jingbo: Hydrogen Bond Mediated Enantioselectivity of Radical Reactions [view]

October 16
Erikah: Difluoromethyl Phenyl Sulfone, a Difluoromethylidene Equivalent: Use in the Synthesis of 1,1-Difluoro-1-Alkenes [view]
Dave: Diastereoselective Phenol para-Alkylation: Access to a Cross-Conjugated Cyclohexadienone en Route to Resiniferatoxin [view]
Nilu: Use of N-N Bond Stereodynamics in Ring-Closing Metathesis to form Medium-Sized Rings and Macrocycles [view]
Tyler: Cross-Coupling of Alkyl Halides with Aryl Grignard Reagents Catalyzed by a Low-Valent Iron Complex [view]
Jim: Cooperative Catalysis of a Cationic Ruthenium Complex, Amine Base, and Na Salt: Catalytic Activation of Acetonitrile as a Nucleophile [view]

September 4
Gil: Highly Enantioselective Catalytic Acyl-Pictet-Spengler Reactions [view]
Michael: Direct Organocatalytic Enantioselective Mannich Reactions of Ketimines: An Approach to Optically Active Quaternary α-Amino Acid Derivatives [view]
Michel: Asymmetric Synthesis Utilizing Circularly Polarized Light by the Photoequilibration of chiral Olefins in Conjunction with Asymmetric Autocatalysis [view]
Beomjun: Relay Ring-Closing Metathesisand Total Synthesis of Oximidine III [view]
Chris: Total Synthesis of (-)-Callystatin A [view]
Corey: StereoselectiveSynthesis of a Topologically Chiral Molecule: The Trefoil Knot [view]

July 24
Jelena: A Report on "Selective Estrogen Receptor Modulators" from the 29th National Medicinal Chemistry Symposium [view]
David: Palladium-Catalyzed Oxygenation of Unactivated sp3 C-H Bonds [view]
Erick: Enantioselective Synthesis of Quaternary Stereocenters via a Catalytic Asymmetric Stetter Reaction [view]
Tamara: Total Syntheses of (+)- and (-)-Cacospongionolide B, Cacospongionolide E, and Related Analogs. Preliminary Study of Structural Features Required for Phospholipase A2 inhibition [view]
Claire: Ligand-, Copper-, and Amine-Free Sonogashira Reactions of Aryl Iodides and Bromides with Terminal Alkynes [view]

June 5
Steve: Catalytic Asymmetric Acylation of (Silyloxy)nitrile Anions [view]
Rob: Syntheses of Hapalosin A, an MDR Reversing Macrocycle [view]
Ruth: Catalytic Asymmetric 1,4-Addition Reactions Using a,b-Unsaturated N-Acylpyrroles as Highly Reactive Monodentate a,b-Unsaturated Ester Surrogates [view]
Tom: A Concise Asymmetric Synthesis of the Marine Hepatotoxin 7-Epicylindrospermopsin [view]
Bryan: α-Aminoallylation of Aldehydes with Ammonia: Stereoselective Synthesis of Homoallylic Primary Amines [view]
Jingbo: Stereospecific and Stereodivergent Construction of Quaternary Carbon Centers through Switchable Directed/Nondirected Allylic Substitution [view]

April 24
Nilu: Triethylborane-Induced Radical Allylation Reaction with Zirconocene-Olefin Complex [view]
Dave: A Novel 1,2-Migration of Acyloxy, Phosphatoxy, and Sulfonyloxy Groups in Allenes: Efficient Synthesis of Tri- and Tetrasubstituted Furans [view]
Erika: Dirhodium(II)tetra(N-(dodecylbenzenesulfonyl)prolinate) Catalyzed Enantioselective Cyclopropenation of Alkynes [view]
Gil: Copper-Catalyzed Tandem Conjugate Addition-Electrophilic Trapping: Ketones, Esters, and Nitriles as Terminal Electrophiles [view]
Jim: Convenient Synthesis of Alkylhydrazides by the Cobalt-Catalyzed Hydrohydrazination Reaction of Olefins and Azodicarboxylates [view]

March 27
Beomjun: Total Synthesis of (+)-SCH351448 [view]
Jelena: Design, Synthesis, and in Vitro Biological Evaluation of Small Molecule Inhibitors of Estrogen Receptor CoactivatorBinding [view]
Tyler: Copper(II)-Catalyzed Highly Enantioselective Addition of Enamides to Imines: The Use of Enamides as Nucleophiles in Asymmetric Catalysis [view]
Michel: A Tandem Semipinacol Rearrangement/Alkylation of α-Epoxy Alcohols: An Efficient and Stereoselective Approach to Multifunctional 1,3-Diols [view]
Mike: Synthesis of Substituted Imidazoles via Organocatalysis [view]
Chris: Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide [view]

February 21
Corey: A Tandem Epoxidation/Stereoselective Intramolecular [4+3] Cycloaddition Reaction Involving Nitrogen-Stabilized Oxyallyl Cations Derived from Chiral Allenamides [view]
Rob: Suzuki Cross-Couplings of Unactivated Secondary Alkyl Bromides and Iodides [view]
Jaehyeon: Stereochemistry of Cyclopropane Formation Involving Group IV Organometallic Complexes [view]
Thomas: Metal-Catalyzed Di-tert-butylsilylene Transfer: Synthesis and Reactivity of Silacyclopropanes [view]
Claire: Polymer-Assisted, Multi-Step Solution Phase Synthesis and Biological Screening of Histone Deacetylase Inhibitors [view]

January 10
Steve: Catalytic Asymmetric Total Syntheses of Quinine and Quinidine [view]
Tamara: Enantioselective Access to 2,7-Cis-Disubstituted Oxepanes: Formal Synthesis of (+)-Isolaurepan [view]
Bryan: Heterobimetallic Catalysis in Asymmetric 1,4-Addition of O-Alkylhydroxylamine to Enones [view]
Jingbo: One-Pot Synthesis of Nitrogen Heterocycles Initiated by Regio and Diastereoselective Carbon-Carbon Bond Formation of Bifunctional Carbonyl Compounds [view]
Erick: Palladium-Catalyzed Multicomponent Coupling of Alkynes, Imines, and Acid Chlorides: A Direct and Modular Approach to Pyrrole Synthesis [view]

2003

December 20
Jim: Synthesis of Optically Pure Arylsilylcarbinols and their Use as Chiral Auxiliaries in Oxacarbenium Ion Reactions [view]
Gil: Diversity-Oriented Synthesis of Tamoxifen-type Tetrasubstituted Olefins [view]
David: Diastereoselective Formation of 7-Membered Oxacycles by Ring-Expansion of Cyclopropanated Galactal [view]
Nilu: One-Pot Three-Component Tandem Metathesis/Diels-Alder Reaction [view]
Erika: Palladium-Imidazolium N-Heterocyclic Carbene- Catalyzed Carbonylative Amidation with Boronic Acids, Aryl Diazonium Ions and Ammonia [view]
Se-Ho: A Stereoselective Synthesis of (-)-Tetrodotoxin [view]

November 8
Chris: Synthesis of Cyclic and Acyclic b-Amino Acids via Chelation-Controlled 1,3-Dipolar Cycloaddition [view]
Beomjun: Diversity Synthesis via C-H Bond Functionalization: Concept Guided Development of New C-Arylation Methods for Imidazoles [view]
Mike: The First Catalytic, Asymmetric a-Additions of Isocyanides. Lewis-Base-Catalyzed, Enantioselective Passerini-Type Reactions [view]
Jelena: Scalability of Microwave-Assisted Organic Synthesis. From Single-Mode to Multimode Parallel Batch Reactors [view]

September 27
Rob: Stachybotrys Metabolites: A History of Mis-Identification [view]
Corey: Partitioning the Loss in Vancomycin Binding Affinity for D-Ala-D-Lac into Lost H-Bond and Repulsive Lone Pair Contributions [view]
Claire: The Direct and Enantioselective Organocatalytic a-Oxidation of Aldehydes [view]
Jaehyeon: Ligand-Free Heck Reaction: Pd(OAc)2 as an Active Catalyst Revisited [view]
Tom: Asymmetric Hydrosilylation of Aryl Ketones Catalyzed by Copper Hydride Complexed by Nonracemic Biphenyl Bis-Phospine Ligands [view]

August 30
Jingbo: A Heterocyclic Nanotube [view]
Nilu: "Mix and Shake" Method for Configurational Assignment by NMR: Application to Chiral Amines and Alcohols [view]
Tamara: Formal Synthesis of (-)-Apicularen [view]
Yasunori: Lewis Acid-Catalyzed Benzannulation via unprecedented [4+2] Cycloaddition of o-Alkynyl(oxo)benzenes and Enynals with Alkynes [view]
Bryan: A General Model for Selectivity in Olefin Cross Metathesis [view]

July 5
Se-Ho: Tandem Polar/Radical Crossover Sequences for the Formation of Fused and Bicyclic Nitrogen Heterocycles Involving Radical Ion Chain... [view]
Steve: Sulfur Ylides via Decarboxylation of Carboxymethylsulfonium Betaines: A Novel and Mild Protocol for the Preparation of Oxiranes [view]
Gil: Asymmetric Schmidt Reaction of Hydroxyalkyl Azides with Ketones [view]
Dave: Addition of Aldehydes and their Equivalents to Electron-Deficient Alkenes using N-Hydroxyphthalimide (NHPI) as a Polarity-Reversal Catalyst [view]
Erika: Hypervalent Iodine(II) Reagents as Safe Alternatives to alpha-Nitro-alpha-diazocarbonyls [view]
Jim: Lewis Base Activation of Lewis Acids: Vinylogous Aldol Reactions [view]