Project-Relevant Literature Club

General guidelines for Project-Relevant Literature Club group meetings are:
• After introducing a brief Safety Nugget, 2-4 Students will present a communication or article of eminent interest to their particular research.
• The reference for this paper should be publicized to all group members by email at least 1 week (7 days) before the meeting. No handouts are required.
• Since everybody should be up-to-date on the content of the paper, the following questions should be addressed in the presentation:
- What is the key innovative aspect of this work?
- How is it relevant to my research project?

- What are experiments I have performed in the past or should perform in the future based on this work?
• Presentations should be planned for ca. 20 min (10 slides).


Group A Group B Group C Group D Group E
Hongdi Paul Cayleigh    
Ethan Ashlyn Eleni    
Micah Clare Tim    


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Historical Topics (Uploads on Web were discontinued in 2019)


August 11
Leila: Enantioselective Synthesis of Oseltamivir Phosphate (Tamiflu) via the Iron-catalyzed Olefin Diazidation [view]
Manwika: Total Synthesis of Salvinorin A [view]
Austin: Breaking Amide Bonds using Nickel Catalysis [view]

June 9
Dishit: C-H Activation Enables a Concise Total Synthesis of Quinine and Analogues with Enhanced Antimalarial Activities [view]
Lauren: Direct β-Alkylation of Ketones and Aldehydes via Pd-Catalyzed Redox Cascade: [view]

May 26
Joe L: Pd/PTABS: Catalyst for Room Temperature Amination of Heteroarenes [view]
Nikhil: Radical Carbofluorination of Unactivated Alkenes with Fluoride Ions [view]
Ruiting: Quaternary Stereocentres Via an Enantioconvergent Catalytic SN1 Reaction [view]

May 12
Steph: Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors [view]
Evan: Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8 [view]

April 14
Leila: Enantioselective Desymmetrization of Cyclobutanones Enabled by Synergistic Palladium/Enamine Catalysis [view]
Prasanth: Total Synthesis of Astellatol [view]
Ettore: Divergent Total Syntheses of Enmein- Type Natural Products: (–)-Enmein, (–)- Isodocarpin, and (–)-Sculponin R [view]

March 17
John M: Palladium-Catalyzed Electrophilic Aromatic C–H Fluorination [view]
Austin: The Story of the Clavilactones [view]

February 17
Dishit: Total Synthesis of the Caged Indole Alkaloid Arboridinine Enabled by aza-Prins and Metal-Mediated Cyclizations [view]
Serene: Ru(II)-Catalyzed Cross-Coupling of Cyclopropenes with Diazo Compounds: Formation of Olefins from Two Different Carbene Precursors [view]
Shikha: Late-Stage Microsomal Oxidation Reduces Drug−Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189 [view]

January 24
Liming: Total Synthesis of the Caged Indole Alkaloid Arboridinine Enabled by aza-Prins and Metal-Mediated Cyclizations [view]
Ruiting: Total Synthesis of (+)-Pleuromutilin [view]
Mike F: Synthesis of α-Chiral Ketones and Chiral Alkanes Using Radical Polar Crossover Reactions of Vinyl Boron-Ate Complexes


December 16
Steph: Total Syntheses of (–)-Majucin and (–)-Jiadifenoxolane A, Complex Majucin-Type Illicium Sesquiterpenes [view]
Keita: Cation Radical Accelerated Nucleophilic Aromatic Substitution via Organic Photoredox Catalysis [view]

November 18
Prasanth: Total Syntheses of Disorazoles A1 and B1 and Full Structural Elucidation of Disorazole B1 [view]
Evan: Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation [view]
Austin: PGM-Catalyzed Cyclization Reactions for the Synthesis of Ergot Alkaloids [view]

October 28
Leila: Direct Synthesis of Amides by Dehydrogenative Coupling of Amines with either Alcohols or Esters: Manganese Pincer Complex as Catalyst [view]
Ruyin: Predicting a Drug's Membrane Permeability: A Computational Model Validated With in Vitro Permeability Assay Data [view]
John: Through-Space Activation Can Override Substituent Effects in Electrophilic Aromatic Substitution [view]

September 2
Dishit: Catalytic Reductive Vinylidene Transfer Reactions [view]
Shikha: Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane [view]
Serene: Parameterization of Phosphine Ligands Demonstrates Enhancement of Nickel Catalysis via Remote Steric Effects [view]

August 5
Joe: Total Synthesis of (+)-Dendrowardol C [view]
Celeste: Evaluation of Oxetan-3-Ol, Thietan-3-Ol, and Derivatives Thereof as Bioisosteres of the Carboxylic Acid Functional Group [view]
Chaemin: Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase Inhibitor [view]
Ruiting: A Concise Enantioselective Total Synthesis of (-)-Virosaine A [view]

July 22
Keita: A Modular and Enantioselective Synthesis of the Pleuromutilin Antibiotics [view]
Joel: Novel OLEDs from Emissive Photopatterned Polymer Brushes [view]
Steph: Asymmetric Radical Bicyclization of Allyl Azidoformates via Cobalt(II)-Based Metalloradical Catalysis [view]

June 24
Mike: Brook Rearrangement as Trigger for Carbene Generation: Synthesis of Stereodefined and Fully Substituted Cyclobutenes [view]
Austin: Synthesis of the Securinega Alkaloids. An Accelerated Intermolecular Rauhut−Currier Reaction Enables the Total Synthesis of (−)-Flueggenine C [view]
Evan: A Concise, Efficient, and Scalable Total Synthesis of Thapsigargin and Nortrilobolide from (R)-(-)-Carvone [view]

June 10
John: Enantioselective Total Synthesis of (+)-Wortmannin [view]
Leila: Batch and Continuous Flow One-Pot Processes using Amine Diazotization to Produce Silylated Diazo Reagents [view]
Serene: Pd(II)-Catalyzed Enantioselective C(sp3)-H Borylation [view]
Ruyin: Structural Basis for Selectivity and Diversity in Angiotensin II Receptors [view]

May 6
Tim: Unified Biomimetic Assembly of Voacalgine A and Bipleiophylline via Divergent Oxidative Couplings [view]
Dishit: Highly Diastereo- and Enantioselective Synthesis of Trifluoromethyl-Substituted Cyclopropanes via Myoglobin-Catalyzed Transfer of Trifluoromethylcarbene [view]
Chaemin: Design and Synthesis of Mercaptoacetamides as Potent, Selective, and Brain Permeable Histone Deacetylase 6 Inhibitors [view]
Liming: Total Syntheses of Highly Oxidized ent-Kaurenoids Pharicin A, Pharicinin B, 7-O-Acetylpseurata C, and Pseurata C: A [5+2] Cascade Approach [ view]

April 15
Mike: Arylation of Hydrocarbons Enabled by Organosilicon Reagents and Weakly Coordinating Anions [view]
Celeste: Investigation of a Bicyclo[1.1.1]Pentane as a Phenyl Replacement Within an LPPLA2 Inhibitor [view]
Ruiting: Stereocontrolled Synthesis of Kalihinol C [view]

March 4
Keita: Stereocontrolled Total Synthesis of (-)-Stemaphylline [view]
Steph: Aldehydes as Alkyl Carbanion Equivalents for Additions to Carbonyl Compounds [view]
Joel: Organocatalytic Stereoselective [8+2] and [6+4] Cycloadditions [view]

February 11
James: Asymmetric Palladium-Catalyzed Alkene Carboamination Reactions for the Synthesis of Cyclic Sulfamides [view]
Evan: PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models [view]
Joe: Electrocatalytic Synthesis of Ammonia at Room Temperature and Atmospheric Pressure from Water and Nitrogen on a Carbon-Nanotube-Based Electrocatalyst [view]

January 21
Liming: Assembly of the Limonoid Architecture by a Divergent Approach: Total Synthesis of (±)-Andirolide N via (±)-8-alpha-Hydroxycarapin [view]
John: Photoredox Activation of CO2 for Amino Acid Synthesis in Continuous Flow [view]
Leila: Copper-Catalyzed Bromination of C(sp3)-H Bonds Distal to Functional Groups [view]


December 24
Steph: Asymmetric Synthesis of Batrachotoxin: Enantiomeric Toxins Show Functional Divergence Against NaV [view]
Mike H: Chemical Synthesis and Self-Assembly of a Ladderane Phospholipid [view]
Tanja: A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models [view]

November 19
Chaemin: Dual Inhibition of PDK1 and Aurora Kinase A: An Effective Strategy to Induce Differentiation and Apoptosis of Human Glioblastoma Multiforme Stem Cells [view]
Mike: Direct Conversion of Nitriles into Alkene Isonitriles [view]
Ruiting: Concise Total Syntheses of (+)-Haplocidine and (+)-Haplocine Via Late-Stage Oxidation of (+)-Fendleridine Derivatives [view]

October 15
Alex C.: A New Platform for the Discovery of New Macroclide Antibiotics [view]
Keita: C−H Functionalization at Sterically Congested Positions by the Platinum-Catalyzed Borylation of Arenes [view]
Serene: Enantioselective Pd-Catalyzed Allylic Alkylation Reactions of Dihydropyrido[1,2-a]indolone Substrates: Efficient Syntheses of (-)-Goniomitine, (+)-Aspidospermidine, and (-)-Quebrachamine [view]

September 10
Joe: Ligand-Accelerated Enantioselective Methylene C(sp3)-H bond activation [view]
James: Design and Synthesis of Novel Bicalutamide and Enzalutamide Derivatives as Antiproliferative Agents for the Treatment of Prostate Cancer [view]
Marina: Blurring the Role of Oligonucleotides: Spherical Nucleic Acids as a Drug Delivery Vehicle [view]
Celeste: Diversity-Oriented Synthesis Yields Novel Multistage Antimalarial Inhibitors [view]

August 6
John: 11-Step Total Synthesis of (–)-Maoecrystal V [view]
Leila: Diverse N-Heterocyclic Ring Systems via Aza-Heck Cyclizations of N-(Pentafluorobenzoyloxy)sulfonamides [view]
Evan: Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor [view]

July 9
Chaemin: Conformational Adaption May Explain the Slow Dissociation Kinetics of Roniciclib (BAY 1000394), a Type I CDK Inhibitor with Kinetic Selectivity for CDK2 and CDK9 [view]
Tanja: Discovery and Characterization of BMN673 (Talazoparib), a Novel, Highly Potent, and Orally Efficacious Poly(ADP-ribose) Polymerase-1,2 Inhibitor, as an Anticancer Agent [view]
Mike H.: Validating Eaton’s Hypothesis: Cubane as a Benzene Bioisostere? [view]

June 19
Ruiting: Enantioselective Synthesis Of An Ophiobolin Sesterterpene Via A Programmed Radical Cascade [view]
Serene: A Syn-Selective Aza-Aldol Reaction Of Boron Aza-Enolates Generated From N-Sulfonyl-1,2,-3-Triazoles And 9-BBN-H [view]
Mike: KOtBu: A Privileged Reagent for Electron Transfer Reactions? [view]

May 21
Alex: Analysis of Nanoparticle Delivery to Tumours [view]
Keita: Catalytic Enantioselective Dihalogenation and the Selective Synthesis of (−)-Deschloromytilipin A and (−)-Danicalipin A [view]
Steph: Expedient Synthesis of (+)-Lycopalhine A [view]

April 9
Evan: Nineteen-step Total Synthesis of (+) - Phorbol [view]
James: Enantioselective Synthesis of Chiral Piperidines via the Stepwise Dearomatization/Borylation of Pyridines [view]
Joe: Expanding the Strained Alkyne Toolbox [view]

March 12
Chaemin: Cell-Penetrating, Guanidinium-Rich Oligophosphoesters: Effective and Versatile Molecular Transporters for Drug and Probe Delivery [view]
Liming: Catalytic Asymmetric Total Synthesis of (−)-Actinophyllic Acid [view]
Celeste: The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat [view]

February 13
John: Strain-Release Amination [view]
Mike H: Enantioselective Total Synthesis of Akuammiline Alkaloids (+)-Strictamine, (–)-2(S)-Cathafoline, and (–)- Aspidophylline A [view]
Marina: 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors [view]

January 16
Celeste: Design of Selective PAK1 Inhibitor G-5555 [view]
Mike: Catalytic Conjunctive Cross-Coupling enabled by Metal-Induced Metallate Rearrangement [view]
Ruiting: Total Synthesis of Gelsenicine via a Catalyzed Cycloisomerization Strategy [view]


December 19
Tanja: Enhanced NIR Radiation-Triggered Hyperthermia By Mitochondrial Targeting [view]
John: Catalytic [2+2+1] Synthesis Of Pyrroles From Alkynes And Diazines Via Ti(II)/Ti(IV) Redox Catalysis [view]
Steph: A Manganese Catalyst for Highly Reactive yet Chemoselective Intramolecular C(sp3)-H Amination [view]

November 21
Evan: An Eight-Step Synthesis of Epicolactone Reveals its Biosynthetic Origin [view]
Joe: Nickel-Catalyzed Suzuki-Miyaura Coupling of Amides [view]
James: Protecting-Group-Free Enantioselective Synthesis of (-)- Pallavicinin and (+)-Neopallavicinin [view]

October 24
Liming: Total Synthesis of Epoxyeujindole A [view]
Alex: Site-Selective Arene C-H Amination via Photoredoxcatalysis [view]

September 26
Raffaele: O–H Hydrogen Bonding Promotes H-Atom Transfer from α C–H Bonds for C-Alkylation of Alcohols [view]
Chaemin: Design of HIV-1 Protease Inhibitors with Amino-bis-tetrahydrofuran Derivatives as P2-Ligands to Enhance Backbone-Binding Interactions: Synthesis, Biological Evaluation, and Protein-Ligand X-ray Studies [view]
Marina: Expanded Porphyrin-Anion Supramolecular Assemblies [view]

August 8
Tanja: (-)-Meptazinol-Melatonin Hybrids as Novel Dual Inhibitors of Cholinesterases and Amyloid-β Aggregation with High Antioxidant Potency for Alzheimer’s Therapy [view]
Ruiting: Palladium-Catalyzed Decarbonylative Dehydration for the Synthesis of α-Vinyl Carbonyl Compounds and Total Synthesis of (−)-Aspewentins A, B, and C [view]
Celeste: Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2 [view]

July 25
Mike: Synergistic Gold and Iron Dual Catalysis: Preferred Radical Addition Toward Vinyl-Gold Intermediate Over Alkene [view]
John: Catalytic Asymmetric Hydroamination of Unactivated Internal Olefins [view]
Evan: Total Synthesis of Gelsemoxonine through a Spirocyclopropane Isoxazolidine Ring Contraction [view]

June 27
Joe: Stereoselective Synthesis of Chiral b-Fluoro α-Amino Acids via Pd(II)-Catalyzed Fluorination of Unactivated Methylene C(sp3)−H Bonds: Scope and Mechanistic Studies [view]
James: Chloroform as a Carbon Monoxide Precursor: In or Ex Situ Generation of CO for Pd-Catalyzed Aminocarbonylations [view]
Steph: Discovery and Reconstitution of the Cycloclavine Biosynthetic Pathway Enzymatic Formation of a Cyclopropyl Group [view]

May 30
Alex: Practical Olefin Hydroamination with Nitroarenes [view]
Zhizhou: Manganese-Catalyzed Late-Stage Aliphatic C−H Azidation [view]
Lalith: Catalytic Asymmetric Total Syntheses of (-)-Galanthamine and (-)-Lycoramine [view]
Liming: Total Synthesis and Structural Revision of (+)-Muironolide A

May 1
Mike: Modular C-H Functionalization Cascade of Aryl Iodides [view]
Chaemin: Nanomolar Inhibitors of the Transcription Factor STAT5b with High Selectivity over STAT5a [view]
Marina: β-Cyclodextrin-threaded Biocleavable Polyrotaxanes Ameliorate Impaired Autophagic Flux in Niemann-Pick Type C Disease [view]

March 28
Raffaele: Ligand-Enabled meta-C–H Activation using a Transient Mediator [view]
Tanja: A New Method for the Preparation of Non-Terminal Alkynes: Application to the Total Synthesis of Tulearin A and C [view]
Ruiting: The Daphniphyllum Alkaloids: Total Synthesis of (−)-Calyciphylline N [view]

February 28
Alex: Bioorthogonal Prodrug Activation Driven by a Strain-Promoted 1,3-Dipolar Cycloaddition [view]
Celeste: Necroptosis-Inducing Rhenium(V) Oxo Complexes [view]
John: Palladium(II)-Catalyzed Enantioselective C-H Arylation of Cyclopropylmethylamines [view]

January 31
James: Rhodium-Catalyzed Borylation of Aryl 2-Pyridyl Ethers through Cleavage of the Carbon–Oxygen Bond: Borylative Removal of the Directing Group [view]
Yongzhao: Catalytic Sterepspecific syn-Dichlorination of Alkenes [view]
Joe: Pd-Catalyzed Intramolecular C-N Bond Cleavage, 1,4-Migration, sp3 C-H Activation, and Heck Reaction: Four Controllable Diverse Pathways Depending on the Judicious Choice of the Base and Ligand [view]

January 3
Liming: Total Synthesis of Rubriflordilactone A [view]
Lalith: Tuning Reactivity and Site Selectivity of Simple Arenes in C-H Activation: Ortho-Arylation of Anisoles via Arene-Metal p-Complexation [view]
Zhizhou: Pseudopterosin Synthesis from a Chiral Cross-conjugated Hydrocarbon through a Series of Cycloadditions [view]


December 6
Raffaele: Catalytic Z-Selective Cross-Metathesis in Complex Molecule Synthesis: A Convergent Stereoselective Route to Disorazole C1 [view]
Chaemin: Promiscuity and Selectivity in Covalent Enzyme Inhibition: A Systematic Study of Electrophilic Fragments [view]
Marina: Small Molecule Antibacterial Peptoid Mimics: The Simpler the Better! [view]

November 8
Tanja: Total Synthesis of (-)-N-Methylwelwitindolinone B Isothiocyanate via a Chlorinative Oxabicycle Ring-Opening Strategy [view]
Nic: A Cascade Strategy Enables a Total Synthesis of (-)-Gephyrotoxin [view]
Ruiting: Total Synthesis of the Tetracyclic Antimalarial Alkaloid (±)-Myrioneurinol [view]
Mike: Total Synthesis of Gracilioether F: Development and Application of Lewis Acid Promoted Ketene-Alkene [2+2] Cycloadditions and Late Stage C-H Oxidation

October 11
Alex: An Interrupted Vinylogous Iso-Nazarov Reaction: Cycloisomerization of Conjugated Trienones to Cyclopenta[b]furan Derivatives [view]
Celeste: Direct Synthesis of Diverse 2-Aminobenzo[b]thiophenes via Palladium-Catalyzed Carbon-Sulfur Bond Formation Using Na2S2O3 as the Sulfur Source [view]
John: A Unified Approach to Lycopodium Alkaloids [view]

September 6
James: A Palladium-Catalyzed Three-Component-Coupling Strategy for the Differential Vicinal Diarylation of Terminal 1,3-Dienes [view]
Yongzhao: An Efficient Strategy Single-Electron-Transfer-Induced Tandem Anion–Radical Reactions [view]
Joe: Palladium-Catalyzed Condensation of N-Aryl Imines and Alkynylbenziodoxolones to Form Multisubstituted Furans

July 5
Liming: Total Synthesis of Taiwaniadducts B, C, and D [view]
Nic: Redox-Triggered C-C Coupling of Alcohols and Vinyl Epoxides [view]
Zhizhou: Air- and Water-Tolerant Rare Earth Guanidinium BINOLate Complexes as Practical Precatalysts in Multifunctional Asymmetric Catalysis [view]

June 7
Ruiting: Total Synthesis of (−)-Lepenine [view]
Raffaele: Total Synthesis of Jiadifenolide [view]
Evan: Therapeutic Targeting of Oncogenic K-Ras by a Covalent Catalytic Site Inhibitor [view]
Tanja: Rhodium(II)-Catalysed Intramolecular Annulation of 1-Sulfonyl-1,2,3-Triazoles with Pyrrole and Indole Rings: Facile Synthesis of N-Bridgehead Azepine Skeletons

May 10
Eakkaphon: Phosphine-Catalyzed Enantioselective γ-Addition of 3-Substituted Oxindoles to 2,3-Butadienoates and 2-Butynoates: Use of Prochiral Nucleophiles [view]
Yongzhao: Iridium-Catalyzed Regioselective Silylation of Secondary Alkyl C−H Bonds for the Synthesis of 1,3-Diols [view]
Alex: anti-Markovnikov Hydroamination of Alkenes Catalyzed by a Two-Component Organic Photoredox System: Direct Access to Phenethylamine Derivatives [view]

April 12
Nic: Four Step Synthesis of the Antimalarial Cardamom Peroxide via an Oxygen Stitching Strategy [view]
John: C-H Methylation of Heteroarenes inspired by radical SAM Transferase [view]
Celeste: Structure-guided Rescaffolding of Selective Antagonists of Bcl-XL [view]
Mike: Decarboxylative Arylation of alpha-Amino Acids via Photoredox Catalysis

March 15
James: SnAP Reagents for the One-Step Synthesis of Medium-Ring Saturated N-Heterocycles from Aldehydes [view]
Seb: Ruthenium-Catalyzed Cascade C-H Functionalization of Phenylacetophenones [view]
Joe: Total Syntheses of (–)-Kopsifoline D and (–)-Deoxoapodine: Divergent Total Synthesis via Late- Stage Key Strategic Bond Formation [view]

February 15
Feng: Total Synthesis of (±)-Distomadines A and B [view]
Steph: Simple, Chemoselective Hydrogenation with Thermodynamic Stereocontrol [view]
Liming: Total Synthesis of (±)-Lundurine B [view]

January 18
Gilmar: Catalyst-Controlled Wacker-Type Oxidation: Facile Access to Functionalized Aldehydes [view]
Josh: Direct Stereospecific Synthesis of Unprotected N-H and N-Me Aziridines from Olefins [view]
Evan: Selective Aurora Kinase Inhibitors Identified Using a Taxol-Induced Checkpoint Sensitivity Screen [view]
Raffaele: Asymmetric Synthesis from Terminal Alkenes by Cascades of Diboration and Cross-Coupling [view]


December 7
Joe: Gold(I)-Catalyzed endo-Selective Intramolecular α-Alkenylation of β-Yne-Furans: Synthesis of Seven- Membered-Ring-Fused Furans and DFT Calculations [view]
Eakkaphon: Rhodium(III)-Catalyzed Azidation and Nitration of Arenes by C-H Activation [view]
Yongzhao: Total Synthesis of Gephyrotoxin by Amide-Selective Reductive Nucleophilic Addition [view]

November 9
Nic: One-Pot Zinc-Promoted Asymmetric Alkynylation/Brook-Type Rearrangement/Ene-Allene Cyclization: Highly Selective Formation of Three New Bonds and Two Stereocenters in Acyclic Systems [view]
Celeste: A New Strategy To Improve The Metabolic Stability Of Lactone [view]
Mike: Cu(OTf)2-Mediated Fluorination of Aryltrifluoroborates with Potassium Fluoride [view]
Catalyst-Controlled Aliphatic C-H oxidation: Prediction and Experiment [view]

October 12
James: Conversion of Azides into Diazo Compounds in Water [view]
Layal: Polypharmacology − Foe or Friend? [view]
Alex: Exploring Natural Product Chemistry and Biology with Multicomponent Reactions. 5. Discovery of a Novel Tubulin-Targeting Scaffold Derived from the Rigidin Family of Marine Alkaloids [view]
Diaminophosphine Oxide Ligand Enabled Asymmetric Nickel-Catalyzed Hydrocarbamoylations of Alkenes [view]

September 21
Steph: Dearomatizing Conjugate Addition to Quinolinyl Amidines for the Synthesis of Dehaloperophoramidine through Tandem Arylation and Allylation [view]
Mustafa: Total Synthesis of Ecteinascidin 743 [view]
Liming: A Concise Total Synthesis of (+)-Scholarisine A Empowered by a Unique C−H Arylation [view]
Total Synthesis of Amphidinolide F [view]

August 24
Kara: A Unified Strategy to ent-Kauranoid Natural Products:  Total Syntheses of (–)-Trichorabdal A and (–)-Longikaurin E [view]
Gilmar: Total Synthesis of the Daphniphyllum Alkaloid Daphenylline [view]
Raffaele: A 14-Step Synthesis of (+)-Ingenol from (+)-3-Carene [view]
Evan: Radical-Based Regioselective C-H Functionalization of Electron-Deficient Heteroarenes: Scope, Tunability, and Predictability

July 13
Josh: Pd-Catalyzed Chemoselective Catellani ortho-Arylation of Iodopyrroles: Rapid Total Synthesis of Rhazinal [view]
Yongzhao: Organocatalytic Oxyamination of Azlactones: Kinetic Resolution of Oxaziridines and Asymmetric Synthesis of Oxazolin-4-ones [view]
Alex: A Small Molecule Bidentate-Binding Dual Inhibitor Probe of the LRRK2 and JNK Kinases [view]
Kyu Ok:
Enantio- and Diastereodivergent Dual Catalysis: α-Allylation of Branched Aldehydes [view]

June 8
Celeste: Preliminary Structure-Activity Relationships and Biological Evaluation of Novel Antitubercular Indolecarboxamide Derivatives Against Drug-Susceptible and Drug-Resistant Mycobacterium tuberculosis Strains [view]
John: Asymmetric Total Synthesis of Transtaganolides A-D and Biosynthetic Implications [view]
Nic: Total Synthesis of the Tubulin Inhibitor WF-1360F Based on Macrocycle Formation through Ring-Closing Alkyne Metathesis [view]
Mike: Iridium-Catalyzed Borylation of Secondary Benzylic C-H Bonds Directed by a Hydrosilane [view]

May 18
Layal: Privileged Scaffolds or Promiscuous Binders: A Glance of Pyrrolo[2,1-f][1,2,4]triazines and Related Bridgehead Nitrogen Heterocycles in Medicinal Chemistry [view]
James: Cu-Catalyzed Synthesis of Diaryl Thioethers and S-Cycles by reaction of Aryl Iodides with Carbon Disulfide in the Presence of DBU [view]
Joe: Nine-Step Enantioselective Total Synthesis of (-)-Vincorine [view]
Fangfei: Fragment-based Drug Design and Identification Of HJC0123, a Novel Orally Bioavailable STAT3 Inhibitor For Cancer Therapy [view]

April 20
Mustafa: Total Synthesis and Determination of the Absolute Configuration of 5,6-Dihydro-α-pyrone Natural Product Synargentolide B [view]
Atefeh: Catalyzed Nitrogenation of Alkynes: A Direct Approach to Nitriles through CΞC Bond Cleavage [view]
: New Mechanistic Insight into the Copper(I)-Catalysed Azide-Alkyne Cycloaddition [view]
Feng: Syntheses of Xanthofulvin and Vinaxanthone, Natural Products Enabling Spinal Cord Regeneration [view]
Liming: Asymmetric Total Synthesis of (−)-Amphidinolide V through Effective Combinations of Catalytic Transformations [view]

March 23
Josh: A New Strategy for Efficient Synthesis of Medium and Large Ring Lactones without High Dilution or Slow Addition [view]
Brandon: Total Synthesis of Cyanolide A in the Absence of Protecting Groups, Chiral Auxiliaries, or Premetalated Carbon Nucleophiles [view]
Raffaele: A Ring-Distortion Strategy to Construct Stereochemically Complex and Structurally Diverse Compounds from Natural Products [view]

February 23
Kara: Late-Stage Deoxyfluorination of Alcohols with PhenoFluor [view]
Kyu Ok: Total Syntheses of Lyconadins A–C [view]
Alex: Systematic Exploration of Dual-Acting Modulators from a Combined Medicinal Chemistry and Biology Perspective [view]
Yongzhao: Total Synthesis of (-)-Flueggine A and (+)-Virosaine B [view]

January 12
Ben: Enantioselective Total Synthesis of Hyperforin [view]
Zhuzhu: Total Synthesis of (-)-Acetylaronotin [view]
Celeste: Assessing the Target Differentiation Potential of Imidazole-Based Protein Kinase Inhibitors



December 1
Jie: Total Synthesis and Stereochemical Revision of the Chlorinated Sesquiterpene (±)-Gomerone C [view]
Jaideep: Boroalkyl Group Migration Provides a Versatile Entry into α-Aminoboronic Acid Derivatives [view]
James Johnson: Rewiring Chemistry: Algorithmic Discovery and Experimental Validation of One-Pot Reactions in the Network of Organic Chemistry [view]
Jared: Total Synthesis and Biological Evaluation of Phidianidines A and B Uncovers Unique Pharmacological Profiles at CNS Targets [view]

November 3
Liming: Total Synthesis of (±)-Communesin F via a Cycloaddition with Indol-2-one [view]
Benjamin: Synthesis of THP Segments of Phorboxazoles by Michael Additions [view]
Feng: Total Synthesis and Biological Activity of the Proposed Structure of Phaeosphaeride A [view]
Mustafa: Total Synthesis of Manzamine A and Related Alkoloids [view]

October 6
Kara: Synthesis of Alkaloid (−)-205B via Stereoselective Reductive Cross-Coupling and Intramolecular [3+2] Cycloaddition [view]
Josh: Transition-Metal-Free Oxyarylation of Alkenes with Aryl Diazonium Salts and TEMPONa [view]
James JJ: (Almost) Everything You Always Wanted to Know About Cancer Stem Cells....
Brandon: A Concise Synthesis of (+)-Artemisinin [view]

August 25
Ben: Bioinspired Total Synthesis of Agelastatin A [view]
Atefeh: Guided Desaturation of Unactivated Aliphatics [view]
: Stereocontrolled Organocatalytic Synthesis of Prostaglandin PGF2α in Seven Steps [view]
Dimas: Enantioselective Total Synthesis of Amphidinolide F [view]
Eric: Total Synthesis of (-)-Isoschizogamine [view]

July 28
Melissa: Rhodium(III)-Catalyzed Dehydrogenative Heck Reaction of Salicylaldehydes [view]
Celeste: A New Class Of Highly Potent And Selective Endomorphin-1 Analogues Containing Α-methylene-β-aminopropanoic Acids (Map) [view]
Zhuzhu: Protecting Group-Free Total Synthesis of (-)-Lannotinidine B [view]

June 9
Elisa: A New Stereocontrolled Synthetic Route to (−)-Echinosporin from D-Glucose via Padwa Allenylsulfone [3+2]-Anionic Cycloadditive Elimination [view]
Jie: Total Synthesis and Stereochemical Reassignment of (±)-Indoxamycin B [view]
Jaideep: Total Synthesis of Chelidonine and Norchelidonine via An Enamide-Benzyne-[2+2] Cycloaddition Cascade [view]
Jared: Scalable Total Synthesis of ( -)-Berkelic Acid by Using a Protecting- Group-Free Strategy [view]
James: The Flight of the (+)-Dactylolide: N-Heterocyclic Carbene Catalyzed Oxidative Macrolactonization: Total Synthesis of (+)-Dactylolide [view]

May 12
Feng: CRTH2 Antagonist MK-7246: A Synthetic Evolution from Discovery through Development [view]
Liming: Enantioselective Total Synthesis and Absolute Configuration of Apiosporic Acid [view]
Mustafa: Total Syntheses of Anominine and Tubingensin A [view]

April 28
Brandon: Total Synthesis of RNA Polymerase Inhibitor Ripostatin B [view]
Yongzhao: Total Synthesis of Loline Alkaloids [view]
Chris: Total Syntheses of Anominine and Tubingensin A [view]

March 31
Dimas: Total Synthesis of (-)-Anisatin [view]
Kara: Total Synthesis of (–)-Dendrobine [view]
Eric: Synthetic (±)-Axinellamines Deficient in Halogen [view]

February 18
Filip: Total Synthesis of (+)-Scholarisine A [view]
Melissa: Phosphorothioic Acids and Related Compounds as Surrogates for H2S Synthesis of Chiral Tetrahydrothiophenes [view]
Zhuzhu: Intraoperative Tumor-Specific Fluorescence Imaging in Ovarian Cancer by Folate Receptor-α Targeting: First in-human Results [view]
Yongzhao: Total Synthesis of (−)-Fusarisetin A [view]

January 7
Jared: Total Synthesis and Structural Revision of the Piperarborenines via Sequential Cyclobutane C-H Arylation [view]
Jie: Total Synthesis of Hapalindoles J and U [view]
Elisa: Dioxindole in Asymmetric Catalytic Systems: Routes to Enantioenriched 3 Substituted 3-Hydroxyoxindoles and the Preparation of Maremycin A [view]


November 26
Igor: Gateway Synthesis of Daphnane Congeners and their Protein Kinase C Affinities and Cell-Growth Activities [view]
Ben: Concise, Stereocontrolled Synthesis of Citrinadin B [view]
Liming: Total Synthesis of (+)-Yohimbine via an Enantioselective Organocatalytic Pictet–Spengler Reaction [view]

November 12
Chris: Enantioselective Total Synthesis of (-)-Acetylaranotin, a Dihydrooxepine Epidithiodiketopiperazine [view]
James JJ: Emerging Drugs to Treat HNSCC: Sensitization of HNSCC to Cisplatin Through the Use of a Novel Curcumin Analog [view]
Ki Bum: Total Synthesis of (+)-Daphmanidin E [view]
Brandon: Total Synthesis of Gelsemoxonine [view]

October 8
Dimas: Total Synthesis of Oxazolomycin [view]
Kara: Total Synthesis of (+)-Decursivine [view]
Eric: Convergent Total Synthesis of (+)-Ophiobolin A [view]
Juraj: Identification of an Unexpected 2-Oxonia[3,3]sigmatropic Rearrangement/Aldol Pathway in the Formation of Oxacyclic Rings. Total Synthesis of (+)-Aspergillin PZ [view]

September 3
Zhuzhu: Selective Killing of Cancer Cells by a Small Molecule Targeting the Stress Response to ROS [view]
Filip: Scalable, Stereocontrolled Total Synthesis of (±)-Axinellamines A and B [view]
Melissa: Total Synthesis of Bryostatin 7 via C−C-Bond-Forming Hydrogenation [view]
Yongzhao: Total Synthesis of (+)-Omphadiol [view]

August 6
Jared: Total Syntheses of Heimiol A, Hopeahainol D, and Constrained Analogues [view]
Jie: Dead Ends and Detours [view]
Nate: Collective Synthesis of Natural Products by Means of Organocascade Catalysis [view]

May 21
Igor: Synthesis of the Stenine Ring System from Pyrrole [view]
Liming: Total Synthesis of (±)-Aspidophylline A [view]
Ben: Total Synthesis of (-)-Conophylline and (-)-Conophyllidine [view]
Brandon: Asymmetric [C+NC+CC] Coupling Entry to the Naphthyridinomycin Natural Product Family: Formal Total Synthesis of Cyanocycline A and Bioxalomycin β2 [view]

May 21
Chris: Total Synthesis of Epicoccin G [view]
Ki Bum: Toward More "Ideal" Polyketide Natural Product Synthesis: A Step-Economical Synthesis of Zincophorin Methyl Ester [view]
Juraj: Asymmetric Total Synthesis of (-)-Scabronine G via Intramolecular Double Michael Reaction and Prins Cyclization [view]
John: Synthesis of (-)-Okilactomycin by a Prins-Type Fragment-Assembly Strategy [view]

April 9
Eric: Total Synthesis of (±)-Alopecuridine and Its Biomimetic Transformation into (±)-Sieboldine A [view]
David: Total Synthesis of N-Methylwelwitindolinone D Isonitrile [view]
Sarang: Enantioselective Total Synthesis of (-) Jiadifenolide [view]

February 26
Melissa: 11-Step Enantioselective Synthesis of (−)-Lomaiviticin Aglycon [view]
Filip: Formal Asymmetric Synthesis of Echinopine A and B [view]
Yongzhao: Asymmetric Total Synthesis of (+)-Danicalipin A [view]
Nolan: Rapid Total Syntheses Utilizing "Supersilyl" Chemistry [view]

January 29
Marija: Concise Total Synthesis of Variocolortides A and B through an Unusual Hetero-Diels-Alder Reaction [view]
Jie: Formal Syntheses of (-)- and (+)-Phalarine [view]
Jared: Enantioselective Total Synthesis of (+)-Salvileucalin B [view]
Nate: The Leiodolide B Puzzle [view]


December 4
Kara: Total Syntheses of the Marine Illudalanes Alcyopterosin I, L, M, N, and C [view]
Dimas: Total Synthesis of Chivosazole F [view]
Sarang: Synthesis of Streptolydigin, a Potent Bacterial RNA Polymerase Inhibitor [view]

October 23
Chad: Total Synthesis of (-)-Nakadomarin A [view]
Jie: Galbulimima Alkaloids (-)-GB 13 and (+)-GB 16 [view]
Eric: Total Synthesis of the Proposed Structure of Briarellin J [view]
Chris: Temporary Restraints to Overcome Steric Obstacles: An Efficient Strategy for the Synthesis of Mycalamide B [view]

September 25
Nolan: Difluorobenzocycloctyne: Synthesis, Reactivity, and Stabilization by beta-Cyclodextrin [view]
Marie-Céline: Total Synthesis and Absolute Stereochemical Assignment of (–)-Communesin F [view]
Ki-Bum: Synthesis of Cortistatins A, J, K, and L [view]
Xueling: Catalytic Enantioselective Alkylative Dearomatization-Annulation: Total Synthesis and Absolute Configuration Assignment of Hyperibone K [view]

September 4
Yongzhao: Total Synthesis of (+)-Fastigiatine [view]
Melissa: Total Synthesis of Virginiamycin M2 [view]
Filip: Total Synthesis of Sporolide B and 9-epi-Sporolide B [view]
John: Room-Temperature Alternative to the Arbuzov Reaction: The Reductive Deoxygenation of Acyl Phosphonates [view]
Sammi: Asymmetric Total Synthesis of Solandelactone E: Stereocontrolled Synthesis of the 2-ene-1,4-diol Core through a Lithiation–Borylation–Allylation Sequence [view]

August 28
David: Asymmetric Total Synthesis of Cylindrocyclophanes A and F through Cyclodimerization and a Ramberg-Bäcklund Reaction [view]
Eric: Total Synthesis of Peloruside A Through Kinetic Lactonization and Relay Ring-Closing Metathesis Cyclization Reactions [view]
Marija: Total Synthesis of All (-)-Agelastatin Alkaloids [view]
Jie: Galbulimima Alkaloids (-)-GB 13 and (+)-GB 16 [view]

July 10
Kara: An Enantioselective Total Synthesis of (+)-Peloruside A [view]
Gary: Synthesis of the QRSTU Domain of Maitotoxin and Its 85-epi-and 86-epi-Diastereomers [view]
Mike: Total Synthesis of (+)-Sieboldine A [view]
Nilesh: Total Synthesis and Structural Reassignment of (+)-Dictyosphaeric Acid A: A Tandem Intramolecular Michael Addition/Alkene Migration Approach [view]

May 22
Sammi: Stereoretentive Suzuki-Miyaura Coupling of Haloallenes Enables Fully Stereocontrolled Access to (−)-Peridinin [view]
Sarang: Total Synthesis and Biological Evaluation of the Resveratrol-Derived Polyphenol Natural Products Hopeanol and Hopeahainol A [view]
Xueling: Total Synthesis of (-)-Anominine [view]
John: Scalable Total Syntheses of N-Linked Tryptamine Dimers by Direct Indole-Aniline Coupling: Psychotrimine and Kapakahines B and F [view]

April 24
Nolan: Enantioselective Synthesis of Englerins A and B [view]
Melissa: Total Synthesis of Coralloidolides A, B, C, and E [view]
Filip: Total Synthesis of (+)-Complanadine A Using an Iridium-Catalyzed Pyridine C-H Functionalization
Marie-Celine: Polycavernoside A: The Prins Macrocyclization Approach [view]

March 27
Jared: Total Synthesis of Kendomycin Featuring Intramolecular Doetz Benzannulation [view]
David: [view]
Marija: Total Synthesis of the Lycorenine-Type Amaryllidaceae Alkaloid Clivonine via a Biomimetic Ring-Switch from a Lycorine-Type Progenitor
Adam: Total Synthesis of Cyclosporine: Access to N-Methylated Peptides via Isonitrile Coupling Reactions [view]

March 6
Gary: Total Synthesis of Echinopines A and B [view]
Kara: Total Synthesis of (+)-Fendleridine and (+)-1-Acetylaspidoalbidine [view]
Mike: Total Synthesis of the Polycyclic Fungal Metabolite (±)-Communesin F
Nilesh: Total Synthesis of Auripyrones A and B and Determination of the Absolute Configuration of Auripyrone B [view]

January 23
Chad: Total Synthesis of Palau’amine [view]
Chris: Total Synthesis of (+)-Isatisine A [view]
Junyan: Anguinomycins and Derivatives: Total Syntheses, Modeling, and Biological Evaluation of the Inhibition of Nucleocytoplasmic Transport
Eric: Total Synthesis of (-)-Mersicarpine [view]


December 26
Tingting: Enantioselective Synthesis of (+)-Cephalostatin 1 [view]
Filip: Chemical and Biological Studies of Nakiterpiosin and Nakiterpiosinone [view]
Rachel: Synthesis of (gamma)-Rubromycin
Marija: Total Synthesis of Spirastrellolide F Methyl Ester [view]

Melissa: Towards Maoecrystal V: A Comparison of Recent Strategies [view]
John: Approaches to the Core of Cortistatin A [view]
Nolan: Total Synthesis of Vinigrol
Marie-Céline: Total Synthesis of (–)-Nakadomarin A [view]

October 3
Nate: Total Syntheses of Isodomoic Acids G and H [view]
Jared: Construction of Two Vicinal Quaternary Carbons by Asymmetric Allylic Alkylation: Total Synthesis of Hyperolactone C and (-)-Biyouyanagin A [view]
Adam: Total Synthesis of (–)-Himandrine
David: Development of a Merged Conjugate Addition/Oxidative Coupling Sequence. Application to the Enantioselective Total Synthesis of Metacycloprodigiosin and Prodigiosin R1 [view]

September 12
Gary: Application of Cross-Conjugated Heteroaromatic Betaines to the Synthesis of the Schizozygane Alkaloid (±)-Strempeliopine [view]
Mike: Enantioselective Total Synthesis of the Marine Toxin (–)-Gymnodimine Employing a Barbier-Type Macrocyclization [view]
Kara: Nine-Step Enantioselective Total Synthesis of (+)-Minfiensine
Karla: Total Synthesis and Study of 6-Deoxyerythronolide B (6-dEB) by late-stage C–H Oxidation [view]

August 15
Chad: Stereoselective Synthesis of β-Hydroxyalleneswith Multiple Contiguous Stereogenic Centers via Aldehyde Addition to α-Alkenyl-Substituted Zirconacyclopentenes [view]
Chenbo: Stereocontrolled Chlorination in Natural Product Synthesis [view]
Eric: A Catalytic, Bronsted Base Strategy for the Intermolecular Allylic C-H Amination

June 20
John: Toward Palau’amine: Hg(OTf)2-Catalyzed Synthesis of the Cyclopentane Core [view]
Nate: Iridium-Catalyzed Asymmetric Isomerization of Primary Allylic Alcohols [view]
Tingting: A Stereocontrolled Total Synthesis of 4-Hydroxydictyolactone
Rachel: Pd-catalyzed Highly Diastereoselective Oxidative Cascade Cyclizations [view]

May 23
Nolan: Enantioselective Synthesis of beta-Iodo Morita-Baylis-Hillman Esters by a Catalytic Asymmetric Three-Component Coupling Reaction [view]
Marie-Celine: Indoles from Simple Anilines and Alkynes: Palladium-Catalyzed C-H Activation Using Dioxygen as the Oxidant [view]
Filip: Lanthanum(III) Triflate-Catalyzed Cyclopropanation via Intramolecular Methylene Transfer
Melissa: A Stereoselective Synthesis of the Bromopyrrole Natural Product (-)-Agelastatin A [view]
David: Negishi Coupling of Secondary Alkylzinc Halides with Aryl Bromides and Chlorides [view]

April 11
Adam: Gold-Catalyzed Homogeneous Oxidative Cross-Coupling Reactions [view]
Maciej: anti-Aminoallylation of Aldehydes via Ruthenium-Catalyzed Transfer Hydrogenative Coupling of Sulfonamido Allenes: 1,2-Aminoalcohols [view]
Marija: A Meta Selective Copper-Catalyzed C-H Bond Arylation
Jared: Two Titanium-Catalyzed Reaction Sequences for Syntheses of Pyrroles from (E/Z)-Chloroenynes or alpha-Haloalkynols [view]
Rob: Total Synthesis of Indolizidine Alkaloid (—)-209D: Overriding Substrate Bias in the Asymmetric Rhodium-Catalyzed [2+2+2] Cycloaddition [view]

February 14
Chris: Asymmetric Synthesis of Medium-Sized Rings by Intramolecular Au(I)-Catalyzed Cyclopropanation [view]
Gary: Cross-Coupling Reactions of Aromatic and Heteroaromatic Silanolates with Aromatic and Heteroaromatic Halides [view]
Karla: Nonlinear Effects (NLE) in Asymmetric Catalysis
Nora: Boron Nitride Nanotubes Are Noncytotoxic and Can Be Functionalized for Interaction with Proteins and Cells [view]

January 17
Carl: A New Efficient Catalytic System for the Chemoselective Cobalt-Catalyzed Cross-Coupling of Aryl Grignard Reagents with Primary and Secondary Alkyl Bromides [view]
Akira: N-Heterocyclization of Naphthylamines with 1,2-and 1,3-Diols Catalyzed by an Iridium Chloride/BINAP System [view]
Chenbo: Direct Cross-Coupling Reaction of Simple Alkenes with AcrylatesCatalyzed by Palladium Catalyst
Eric: A Copper-Catalyzed Tandem Synthesis of Indolo- and Pyrrolo[2,1-a]isoquinolines [view]
Chad: Palladium-Catalyzed Annulation of Acyloximes with Arynes (or Alkynes): Synthesis of Phenanthridines and Isoquinolines [view]


December 20
Melissa: Dicobalt Hexacarbonyl Complexes of Alkynyl Imines in a Sequential Staudinger/Pauson-Khand Process.  A Route to New Fused Tricyclic β-Lactams [view]
Kalyani: Nickel-Catalyzed Decarbonylative Addition of Anhydrides to Alkynes [view]
John: Mechanistic Studies on the Copper-Catalyzed N-Arylation of Amides
Tingting: Efficient Formation of Ring Structure Utilizing Multisite Activation by Indium Catalysis [view]

October 18
Filip: Direct Catalytic Asymmetric Addition of Allylic Cyanides to Ketoimines [view]
Laurent: Pushing the Limits of the Metathesis Reaction: Design of the NHC ligand [view]
Nate: Synthesis of Cyclobutenes by Highly Selective Transition-Metal-Catalyzed Ring Expansion of Cyclopropanes
Nolan: [(NHC)2Cu]X Complexes as Efficient Catalysts for Azide-Alkyne Click Chemistry at Low Catalyst Loadings [view]

September 26
Maciej: Intramolecular Arylcyanation of Alkenes [view]
Adam: Reactivity of (2-Alkenyl-3-pentene-1,5-diyl)iron Complexes: Preparation of Functionalized Vinylcyclopropanes and Cycloheptadienes [view]
Jared: Palladium-Catalyzed Intramolecular Coupling of Arenes and Unactivated Alkanes in Air
Li: Intra/Intermolecular Direct Allylic Alkylation via Pd(II)-Catalyzed Allylic C-H Activation [view]
John: Efficient Iron-Catalyzed N-Arylation of Aryl Halides with Amines [view]

August 30
Gary: Palladium-Catalyzed Reactions of Arylindium Reagents Prepared Directly from Aryl Iodides and Indium Metal [view]
Nora: Sonogashira Couplings of Aryl Bromides: Room Temperature, Water Only, No Copper [view]
Rob: Intramolecular Huisgen-Type Cyclization of Platinum-Bound Pyrylium Ions with Alkenes and Subsequent Insertion into a Benzylic C-H Bond
Amol: Synthesis of 1,1-Disubstituted Olefins via Catalytic Alkyne Hydrothiolation/ Kumada Cross Coupling [view]
Karla: Branched-Regioselective Hydroformylation with Catalytic Amounts of a Reversibly Bound Directing Group [view]
David: Direct and Selective Arylation of Tertiary Silanes with Rhodium Catalyst [view]

July 19
Marija: Construction of Aryliridium – Salen Complexes: Enantio- and Cis-Selective Cyclopropanation of  Conjugated and Nonconjugated Olefins [view]
Jitendra: Arylhalide-Tolerated Electrophilic Amination of Arylboronic Acids with N-Chloroamides Catalyzed by CuCl at Room Temperature [view]
Chenbo: The Total Synthesis of (-)-Cyanthiwigin F by Means of Double Catalytic Enantioselective Alkylation
Eric: Pd-Catalyzed Sequential Reactions via Allene Intermediate for the Synthesis of Polycyclic Frameworks Containing 2,3-Dihydrofuran Units [view]
Chad: Water-Mediated Catalyst Preactivation: An Efficient Protocol for C-N Cross-Coupling Reaction [view]

June 28
Chris: One-Pot Synthesis of Highly Functionalized Pyridines via a Rhodium Carbenoid Induced Ring Expansion of Isoxazoles [view]
Julia: Gold(I)-Catalyzed Cycloisomerization of 1,7- and 1,8-Enynes: Application to the Synthesis of a New Allocolchicinoid [view]
Kalyani: Rhenium-Catalyzed Synthesis of Multisubstituted Aromatic Compounds via C-C Single-Bond Cleavage
Akira: Catalytic Enantioselective Allyl- and Crotylboration of Aldehydes Using Chiral Diol•SnCl4 Complexes. Optimization, Substrate Scope and Mechanistic Investigations [view]
Tingting: Ruthenium-Catalyzed Azide-Alkyne Cycloaddation: Scope and Mechnism [view]
Nate: Zinc-Catalyzed Enantiospecific sp3-sp3 Cross-Coupling of alpha-Hydroxy Ester Triflates with Grignard Reagents [view]

May 31
Jennie: Copper-Catalyzed Reaction of Alkyl Halides with Cyclopentadienylmagnesium Reagent [view]
Laurent: Iron –Catalyzed Direct Arylation through Directed C-H Bond Activation [view]
Filip: Diastereoselective Nickel-Catalyzed Reductive Aldol Cyclizations Using Diethylzinc as the Stoichiometric Reductant: Scope and Mechanistic Insight
David: Asymmetric Copper-Catalyzed Synthesis of alpha-Amino Boronate Esters from N-tert-Butanesulfinyl Aldimines [view]
Amir: Cancer Wars - The Metastasis Strikes Back [view]
Bryan: Highly Reactive, General and Long-Lived Catalysts for Palladium-Catalyzed Amination of Heteroaryl and Aryl Chlorides, Bromides, and Iodides: Scope and Structure-Activity Relationships [view]

April 26
Adam: Total Syntheses of Minfiensine [view]
Zhiyong: New Chemistry with Old Functional Groups: On the Reaction of Isonitriles with Carboxylic Acids-A Route to Various Amide Types
Maciej: Asymmetric Synthetic Access to the Hetisine Alkaloids:Total Synthesis of (+)-Nominine [view]
Li: Site-Specific ProdrugRelease Using Visible Light [view]

March 29
Karla: A Multifaceted Phosphate Tether: Application to the C15-C30 Subunit of Dolabelides A-D [view]
David:Tandem Rh(I)-Catalyzed [(5+2)+1] Cycloaddition/Aldol Reaction for the Construction of Linear Triquinane  Skeleton:Total Syntheses of (+)-Hirsutene and (+)-1-Desoxyhypnophilin
Josh: A Concise Approach to Vinigrol [view]
Melissa: Baran Lab Syntheses of the Axinellamines [view]
Abhisek: Ring Opening/Fragmentation of Dihydropyrones for the Synthesis of Homopropargyl Alcohols [view]
Rob: Powdered KOH in DMSO: An Efficient Base for Asymmetric Cyclization via Memory of Chirality at Ambient Temperature [view]

February 16
Shuli: Total Synthesis of Platencin [view]
Kalyani: Concise Total Synthesis of (+)-WIN 64821 and (-)-Ditryptophenaline [view]
Chad: A Palladium-Catalyzed Alkylation/Direct Arylation Synthesis of Nitrogen-Containing Heterocycles
Marija: Synthesis of the Sporolide Ring Framework through a Cascade Sequence Involving an Intramolecular [4+2] Cycloaddition Reaction of an o-Quinone [view]
Chenbo: Alkynes as StilleReaction Pseudohalides: Gold- and Palladium-CocatalyzedSynthesis of Tri-and Tetra-Substituted Olefins [view]
Jitendra: Concise Enantioselective Total Syntheses of (+)-Homochelidonine, (+)-Chelamidine, (+)-Chelidonine, (+)-Chelamine and (+)-Norchelidonine via a Pd (II)-catalyzed Ring-Opening Strategy [view]

January 5
John: Facile preparation of alpha-amino ketones from oxidative ring-opening of aziridines by pyridine N-oxide [view]
Julia: An Efficient Synthetic Approach to Cyanocycline A and Bioxalomycin beta2 via [C+NC+CC] coupling [view]
Jennifer: Total Synthesis of (+/-)-Goniomitine via a Formal Nitrile/Donor-Acceptor Cyclopropane [3 + 2] Cyclization
Masafumi: Thiol-Catalyzed Stereoselective Transfer Hydroamination of Olefins with N-Aminated Dihydropyridines [view]


November 24
Filip: Asymmetric Allylboration of Acyl Imines Catalyzed by Chiral Diols [view]
Bryan: An Unexpected Organocatalytic Asymmetric Tandem Michael/Morita-Baylis-Hillman Reaction [view]
Total Synthesis of (-)-Okilactomycin [view]
Lisa: Acid Catalysed Rearrangement of Fused Alkylideneoxetanols [view]
Maciej: A Predictably Selective Aliphatic C–H Oxidation Reaction for Complex Molecule Synthesis [view]

October 27
Amir: A Minimal Peptide Sequence That Targets Fluorescent and Functional Proteins into the Mitochondrial Intermembrane Space [view]
Adam: Silenes in organic synthesis: a concise synthesis of (±)-epi-picropodophyllin [view]
David W.: Total Synthesis of Resveratrol-Based Natural Products: A ChemoselectiveSolution
Melissa: Lewis Base Activation of Lewis Acids: Development of a Lewis Base Catalyzed Selenolactonization [view]
Bill: Differentiation of Nonconventional “Carbanions” – The Total Synthesis of Nemorosone and Clusianone [view]
Erikah: Total Synthesis of (-)-Sarain A [view]

September 15
Chad: Palladium-Catalyzed Synthesis of Cyclopentane-Fused Benzocyclobutenes via Tandem Directed Carbopalladation/C-H Bond Functionalization [view]
Shuli: TransannularRearrangement of Activated Lactams: Stereoselective Synthesis of Substituted Pyrrolidine-2,4-diones from Diketopiperazines [view]
A Practical, Enantioselective Synthetic Route to a Key Precursor to the Tetracycline Antibiotics [view]
Chenbo: Synthesis of Azadirachtin: A Long but Successful Journey [view]
Julia: Total Synthesis of (+)-Suaveolindole [view]
Marija: Epoxide-Opening Cascades Promoted by Water [view]

August 18
Akira: Approach to the Homoerythrina Alkaloids Using a Tandem N-Alkylation/Azomethine Ylide Cycloaddition [view]
John M.: Total Synthesis of Kinamycins C, F, and J [view]
Korede: Highly Stereoselective Prins Cyclization of (Z)- and (E)-Brominated Homoallylic Alcohols to 2,4,5,6-Tetrasubstituted Tetrahydropyrans
Amol: Metal-Catalyzed Regiodivergent Cyclization of gamma-Allenols: Tetrahydrofurans versus Oxepanes [view] & Lewis Acid Promoted Imine Synthesis [view]
Jennifer: Total Synthesis of Solandelactones E and F, Homoeicosanoids from the Hydroid Solanderia Secunda [view]

July 28
David A.: Enantioselective Friedel-Crafts Alkylations Catalyzed by Bis(oxazolinyl)pyridine – Scandium(III) Triflate Complexes [view]
Lisa: Synthesis of the Entire Carbon Framework of the Keracidin Chromophore Aglycon [view]
Filip: A Practical Synthesis of (-)-Oseltamivir
Melissa: Construction of Tetrahydrofurans by Pd(II)/Pd(IV)-Catalyzed Aminooxygenation of Alkenes [view]
Josh: Total Synthesis, Stereochemical Reassignment, and Absolute Configuration of Chlorofusin [view]
Bryan: Copper-Catalyzed Tethered Aziridination of Unsaturated N-Tosyloxy Carbamates [view]

June 16
Zhiyong: Total Synthesis and Revised Structure of Biyouyanagin A [view]
Erikah: Enantioselective Total Synthesis of (-)-Salinosporamide A (NPI-0052) [view]
Amir: Synthesis of Nitric Oxide-Releasing Silica Nanoparticles
David W.: The Catalytic Cross-Coupling of Unactivated Arenes [view]
Shuli: A Diosphenol-Based Strategy for the Total Synthesis of (-)-Terpestacin [view]
Maciej: A New Multicomponent Reaction Catalyzed by [Lewis acid]+[Co(CO)4]-Catalyst [view]

May 12
Chad: Enantioselective Synthesis of (+)-Majusculone [view]
Bill: Total Synthesis of (+)-Strychnine via a [4+2]-Cycloaddition/Rearrangement Cascade [view]
Maciej: Direct, Catalytic Hydroaminoalkylation of Unactivated Olefins with N-Alkyl Arylamines
Chenbo: Chiral N-Heterocyclic Carbenes in Natural Product Synthesis: Application of Ru-Catalyzed Asymmetric Ring-Opening/Cross-Metathesis and Cu-Catalyzed Allylic Alkylation to Total Synthesis of Baconipyrone C [view]
Kalyani: Mild Cobalt-Catalyzed Hydrocyanation of Olefins with Tosyl Cyanide [view]
Marija: Gold(I)-Catalyzed Bis-Spiroketalization: Synthesis of the Trioxadispiroketal-Containing A-D Rings of Azaspiracid [view]

April 7
Adam: Sequential Silylcarbocyclization/Silicon-Based Cross-Coupling Reactions [view]
John M.: Nucleophilic Addition to a p-Benzyne Derived from an Enediyne: A New Mechanism for Halide Incorporation into Biomolecules [view]
Kalyani: Enantioselective Total Synthesis of the Osteoclastogenesis Inhibitor (+)-Symbioimine
Julia: Total Syntheses of (+)-Lyconadin A and (-)-Lyconadin B [view]
Jennifer: Unified, Radical-Based Approach for the Synthesis of Spiroketals [view]

March 3
Nilu: Total Synthesis of Jerangolid D [view]
David A.: Mild and Selective Hydrozirconation of Amides to Aldehydes Using Cp2Zr(H)Cl: Scope and Mechanistic Insight [view]
John: Effect of Substitution on the Intramolecular 1,3-Dipolar Cycloaddition of Alkene Tethered Münchnones
Lisa: Cyclisation Reaction of Cyano-Substituted Unsaturated Esters Promoted By Conjugate Addition Of Organoborons [view]
Cody: Multicomponent Reactions Involving Tricyclooxonium Ylide Intermediate: Diastereoselective Synthesis of Mono- and Bisalkoxyoctahydro-1,4-benzodioxocin-6(5H)-one Frameworks [view]

February 16
Adam: Asymmetric Total Syntheses of (+)-3-(Z)-Laureatin and (+)-3-(Z)-Isolaureatin by “Lone Pair-Lone Pair Interaction-Controlled” Isomerization [view]
David W.: Biogenetic hypothesis and first steps towards a biomimetic synthesis of haouamines [view]
Erikah: Intramolecular Cyclobutadiene Cycloaddition/Cyclopropanation/Thermal Rearrangement: An Effective Strategy for the Asymmetric Syntheses of Pleocarpenene and Pleocarpenone
Bryan: Highly Enantioselective Friedel-Crafts Reaction of Indoles with Imines by a Chiral Phosphoric Acid [view]
Bill: Domino Ring-Opening/Recyclization Reactions of Doubly Activated Cyclopropanes as a Strategy for the Synthesis of Furoquinoline [view]
Amir: Targeting Antioxidants to Mitochondria [view]

January 7
Stephan:Asymmetric Synthesis of a-Substituted Allyl Boranes and Their Application in the Synthesis of Iso-agatharesinol [view]
Zhiyong: Catalytic Enantioselective Mannich-type Reactions of Ketoimines [view]
Shuli: A Sakurai-Prins-Ritter Sequence for the Three-Component Diastereoselective Synthesis of 4-Amino Tetrahydropyrans [view]
Chenbo: Vanadium-Catalyzed Asymmetric Epoxidation of Homoallylic Alcohols [view]
Amol: Enantioselective Total Synthesis of (+)-Homochelidonine by a PdII- Catalyzed Asymmetric Ring-Opening Reaction of a meso-Azabicyclic Alkene with an Aryl Boronic Acid [view]


November 25
Kalyani: Lewis Base Activation of Grignard Reagents with N-Heterocyclic Carbenes. Cu-Free Catalytic Enantioselective Additions to γ-Chloro-α,β-Unsaturated Esters [view]
Josh: Asymmetric Total Synthesis of (+)- and ent-(-)-Yatakemycin and Duocarmycin SA: Evaluation of Yatakemycin Key Partial Structures and Its Unnatural Enantiomer [view]
Mapping the Landscape of Potentially Primordial Informational Oligomers [view]
Jennifer: Magnesium Iodide Promoted Ring Expansion of Secondary Methylenecyclopropyl Amides [view]
Julia: Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras [view]

October 28
John: xDNA: A New Genetic System? [view]
Bryan: Total Synthesis of Antheliolide A [view]
Stereoselective Synthesis of N-Alkylaziridines from N-Chloroamines [view]
David A: Palladium-Mediated Functionalization of Heteroaromatic Cations: Comparative Study on Quinolizinium Cations [view]

September 30
Bill: Total Synthesis of (-)-Himgaline [view]
Stephan: Enantioselective Total Synthesis of Guanacastepene Using an Uncommon 7-Endo Heck Cyclization as a Pivotal Step [view]
Adam: The Hexacyclinol Incident
David W: Small-Molecule Activation of Procaspase-3 to Caspase-3 as a Personalized Anticancer Strategy [view]
Nilu: Palladium-Catalyzed Alkylation of sp2 and sp3 C-H Bonds with Methylboroxine and Alkylboronic Acids: Two Distinct C-H Activation Pathways [view]

August 12
Chenbo: Pd-Catalyzed α-Arylation of Trimethylsilyl Enol Ethers with Aryl Bromides and Chlorides [view]
Erikah: Strain Release Rearrangement of N-Vinyl-2-Aziridines. Total Synthesis of the Anti-Leukemia Alkaloid (-)-Deoxyharringtonine [view]
Zhiyong: Total Synthesis of Iejimalide B
Grace: Synthetic Studies on Quinine: Quinuclidine Construction via a Ketone Enolate Regio-and Diastereoselective Pd-Mediated Allylic Alkylation [view]

July 1
Kalyani: Total Synthesis and Stereochemistry of Pinnatoxins B and C [view]
Julia: Reductive Carbodiazenylation of Nonactivated Olefins via Aryl Diazonium Salts [view]
Maciej: Total Syntheses of Amphidinolide X and Y
Tom: Glycerol as a Source of Fuels and Chemicals by Low-Temperature Catalytic Processing [view]
John: Highly Diastereoselective Asymmetric Mannich Reactions of 1,3-Dicarbonyls with Acyl Imines [view]

May 6
Bryan: New Synthetic Routes to Tamiflu [view]
Erick: New Methods of Indole Formations and Applications in Total Synthesis [view]
Zhenyu: Asymmetric Reduction of Oxime Ethers
Dhana: Preparation of Annulated Nitrogen Containing Heterocycles via a One-Pot Palladium-Catalyzed Alkylation/Direct Arylation Sequence [view]
David: Axially Chiral Biaryl Diols Catalyze Highly Enantioselective Hetero-Diels-Alder Reactions Through Hydrogen Bonding [view]

April 1
Adam: Enantioselective Synthesis of Cyclic Enol Ethers and All-Carbon Quaternary Stereogenic Centers Through Catalytic Asymmetric Ring-Closing Metathesis [view]
Shinya: Mechanistic Implications in the Morita–Baylis–Hillman Alkylation: Isolation and Characterization of an Intermediate [view]
Erikah: A Synthesis of (+)-Saxitoxin
Michel: Nickel-Catalyzed Three-Component [3+2+2] Cocyclization of Ethyl Cyclopropylideneacetate and Alkynes [view]
Juan: Total Synthesis of (±)-Haouamine A [view]
David: Rising Stars Of Synthesis: The Post-doctoral work of Scott A. Snyder [view]

March 4
Nilu: Tetraarylphosphonium Salts as Solubility-Control Groups: Phosphonium-Supported Triphenylphosphine and Azodicarboxylate Reagents [view]
Zhenglai: Asymmetric Catalysis by Chiral Hydrogen-Bond Donors [view]
Chenbo: Ladder Polyether Synthesis via Epoxide-Opening Cascades Using a Disappearing Directing Group
Grace: Enantioselective Meerwein-Schmidt-Ponndorf-Verley (MSPV) Reduction of Ketimines Using 2-Propanol and (BINOL)Al III [view]
Stephan: Platinum- and Gold-Catalyzed Rearrangement Reactions of PropargylAcetates: Total Synthesis of (-)-α-Cubebene, (-)-Cubebol, Sesquicarene and related Terpenes [view]
Zhiyong: Chemoselective Amide Ligations by Decarboxylative Condensations of N-Alkylhydroxylamines and a-Ketoacids [view]

January 21
Josh: Total Synthesis of Salinosporamide A [view]
Kalyani: Bifunctional Thiourea-Catalyzed Diastereo- and Enantioselective Aza-Henry Reaction [view]
Claire: Microwave-Assisted Concise Total Syntheses of Quinazolinobenzodiazepine Alkaloids
Markus: Iron in the Service of Chromium: The ortho-Benzannulation of trans,trans-Dienyl Fischer Carbene Complexes [view]
Tom: Group 4 Metals in Polyketide Synthesis: A Convergent Strategy for the Synthesis of Polypropionate-Derived (E,E)-Trisubstituted 1,3-Dienes [view]
Maciej: Recent Applications of Chiral Silicon Reagents [view]


October 15
Erick: Enantioselective Organo-Cascade Catalysis [view]
Adam: Highly Enantio- and Diastereoselective One-Pot Synthesis ofAcyclic Epoxy Alcohols and Allylic Epoxy Alcohols [view]
Ruth: Group Selective Enyne RCM [view]
Anthony: Total Synthesis of (±)-Garsubellin A [view]
Dhana: Total Synthesis of (-)-SNF4435 C and (+)-SNF 4435 D [view]
Jingbo: A Diels-Alder Macrocyclization Enables an Efficient Asymmetric Synthesis of the Antibacterial Natural Product Abyssomicin C [view]

September 3
Erikah: Deoxygenation of Alcohols employing Water as the Hydrogen Atom Source [view]
David: Studies toward the Synthesis of Azadirachtin: Total Synthesis of a Fully Functionalized ABC Framework and Coupling with a Norbornene Domain [view]
Nilu: Interrupted Nazarov Cyclization on Silica Gel [view]
Shinya: Synthesis of the Tetrahydroisoquinoline Alkaloid (±)-Renieramycin G and a (±)-Lemonomycinone Analogue from a Common Intermediate [view]
Josh: Total Synthesis of Thiostrepton [view]
Bryan: Iodomethylzinc Phosphates: Powerful Reagents for the Cyclopropanation of Alkenes [view]

June 25
Grace: A Highly Efficient Organocatalyst for Direct Aldol Reactions of Ketones and Aldehydes [view]
Michel: DNA-Based Asymmetric Catalysis [view]
Mike: Stereochemical Memory Effects in Alkene Radical Cation/Anion Contact Ion Pairs: Effect of Substituents and Models for Diastereoselectivity [view]
Tyler: Total Synthesis of the Neotropical Poison-Frog Alkaloid (-)-205B [view]
Chenbo: Organophosphorus Esters of 1-Hydroxy-7-azabenzotriazole: A New Peptide Couping Reagent [view]

June 4
Claire: Spiro-Cyclopropanation from Oxoallylsilanes [view]
David: High Performance of Rh(Phebox) Catalysts in Asymmetric Reductive Aldol Reaction: High Anti-Selectivity [view]
Graciela: Molybdenum Oxides as Highly Effective Dehydrative Cyclization Catalysts for the Synthesis of Oxazolines and Thiazolines [view]
Tom: Spinosyn G: Proof of Structure by Semisynthesis [view]
Markus: Absolute Asymmetric Photocyclization of Isopropylbenzophenone Derivatives Using a Cocrystal Approach Involving Single-Crystal-to-Single-Crystal Transformation [view]
Maciej: The Tetracycline Antibiotics [view]

April 30
Erikah: Tetraorganosilicon Reagents for the Silicon-Based Cross-Coupling Reaction [view]
Jingbo: Gold-Catalyzed Assembly of Heterobicyclic Systems [view]
Anthony: A Modular Approach to Polyketide Building Blocks: Cycloadditions of Nitrile Oxides and Homoallylic Alcohols [view]
Juan: Enantioselective Synthesis of Stephacidin B [view]
Bryan: Catalytic Enantioselective Construction of All-Carbon Quaternary Stereocenters: Synthetic and Mechanistic Studies of the C-Acylation of Silyl Ketene Acetals [view]
Ruth: Total Synthesis of Antascomincin B [view]

April 2
Michel: Stereoselective Transformations of Trihalomethylcarbinols Induced by Chromous Chloride [view]
Erick: Direct C-Arylation of Free (NH)-Indoles and Pyrroles Catalyzed by Ar–Rh(III) Complexes Assembled In Situ [view]
David: The Direct Coupling Of Carbonyl Compounds With Indoles And Pyrroles [view]
Gil: Cooperative Catalysis by General Acid and Base Bifunctionalized Mesoporous Silica Nanospheres [view]
Jim: The Direct Acyl-Alkylation of Arynes [view]

February 26
Grace: Stereocontrolled Synthesis of Angularly Substituted 1-Azabicyclic Rings by Cationic 2-Aza-Cope Rearrangement [view]
Jelena: A Quantitative Cell-Based High-Content Screening Assay for the Epidermal Growth Factor Receptor-Specific Activation of Mitogen-Activated Protein Kinase [view]
Tyler: Enantioselective Direct Intermolecular Aldol Reactions with Enantiotopic Group Selectivity and Dynamic Kinetic Resolution [view]
Mike: Asymmetric Total Synthesis of (–)-Agelastatin A Using Sulfinimine (N-Sulfinyl Imine) Derived Methodologies [view]
Nilu: Dynamic Ligand Exchange of the Lanthanide Complex Leading to Structural and Functional Transformation: One Pot Sequential Catalytic Asymmetry Epoxidation-Regioselective Epoxide-Opening Process [view]

January 15
Tamara: Method for the Rapid Synthesis of Highly Functionalized 2-Hydroxy-1-naphthoates. Synthesis of the Naphthoic Acid Components of Neocarzinostatin Chromophore and N1999A2 [view]
Claire: A Fluorous-Phase Pummerer Cyclative-Capture Strategy for the Synthesis of Nitrogen Heterocycles [view]
Corey: Total Synthesis of Ingenol [view]
David: Nozaki-Hiyama-Kishi Chromium Couplings [view]
Graciela: Nickel-Catalyzed Addition of Dimethylzinc to Aldehydes across Alkynes and 1,3-Butadiene: An Efficient Four-Component Connection Reaction [view]


November 27
Bryan: Regiospecific Functionalization of Methyl C-H Bonds of Allkyl Groups in Reagents with Heteroatom Functionality [view]
Ruth: Ruthenium- and Platinum-Catalyzed Sequential Reactions: Selective Synthesis of Fused Polycyclic Compounds from Propargylic Alcohols and Alkenes [view]
Tom: Meerwein-Ponndorf-Verley Alkynylation of Aldehydes: Essential Modification of Aluminum Alkoxides for Rate Acceleration and Asymmetric Synthesis [view]
Erick: Direct Oxidative Heck Cyclizations: Intramolecular Fujiwara-Moritani Arylations for the Synthesis of Functionalized Benzofurans and Dihydrobenzofurans [view]
Jingbo: Hydrogen Bond Mediated Enantioselectivity of Radical Reactions [view]

October 16
Erikah: Difluoromethyl Phenyl Sulfone, a Difluoromethylidene Equivalent: Use in the Synthesis of 1,1-Difluoro-1-Alkenes [view]
Dave: Diastereoselective Phenol para-Alkylation: Access to a Cross-Conjugated Cyclohexadienone en Route to Resiniferatoxin [view]
Nilu: Use of N-N Bond Stereodynamics in Ring-Closing Metathesis to form Medium-Sized Rings and Macrocycles [view]
Tyler: Cross-Coupling of Alkyl Halides with Aryl Grignard Reagents Catalyzed by a Low-Valent Iron Complex [view]
Jim: Cooperative Catalysis of a Cationic Ruthenium Complex, Amine Base, and Na Salt: Catalytic Activation of Acetonitrile as a Nucleophile [view]

September 4
Gil: Highly Enantioselective Catalytic Acyl-Pictet-Spengler Reactions [view]
Michael: Direct Organocatalytic Enantioselective Mannich Reactions of Ketimines: An Approach to Optically Active Quaternary α-Amino Acid Derivatives [view]
Michel: Asymmetric Synthesis Utilizing Circularly Polarized Light by the Photoequilibration of chiral Olefins in Conjunction with Asymmetric Autocatalysis [view]
Beomjun: Relay Ring-Closing Metathesis and Total Synthesis of Oximidine III [view]
Chris: Total Synthesis of (-)-Callystatin A [view]
Corey: StereoselectiveSynthesis of a Topologically Chiral Molecule: The Trefoil Knot [view]

July 24
Jelena: A Report on "Selective Estrogen Receptor Modulators" from the 29th National Medicinal Chemistry Symposium [view]
David: Palladium-Catalyzed Oxygenation of Unactivated sp3 C-H Bonds [view]
Erick: Enantioselective Synthesis of Quaternary Stereocenters via a Catalytic Asymmetric Stetter Reaction [view]
Tamara: Total Syntheses of (+)- and (-)-Cacospongionolide B, Cacospongionolide E, and Related Analogs. Preliminary Study of Structural Features Required for Phospholipase A2 inhibition [view]
Claire: Ligand-, Copper-, and Amine-Free Sonogashira Reactions of Aryl Iodides and Bromides with Terminal Alkynes [view]

June 5
Steve: Catalytic Asymmetric Acylation of (Silyloxy)nitrile Anions [view]

Rob: Syntheses of Hapalosin A, an MDR Reversing Macrocycle [view]
Ruth: Catalytic Asymmetric 1,4-Addition Reactions Using a,b-Unsaturated N-Acylpyrroles as Highly Reactive Monodentate a,b-Unsaturated Ester Surrogates [view]
Tom: A Concise Asymmetric Synthesis of the Marine Hepatotoxin 7-Epicylindrospermopsin [view]
Bryan: α-Aminoallylation of Aldehydes with Ammonia: Stereoselective Synthesis of Homoallylic Primary Amines [view]
Jingbo: Stereospecific and Stereodivergent Construction of Quaternary Carbon Centers through Switchable Directed/Nondirected Allylic Substitution [view]

April 24
Nilu: Triethylborane-Induced Radical Allylation Reaction with Zirconocene-Olefin Complex [view]
Dave: A Novel 1,2-Migration of Acyloxy, Phosphatoxy, and Sulfonyloxy Groups in Allenes: Efficient Synthesis of Tri- and Tetrasubstituted Furans [view]
Erika: Dirhodium(II)tetra(N-(dodecylbenzenesulfonyl)prolinate) Catalyzed Enantioselective Cyclopropenation of Alkynes [view]
Gil: Copper-Catalyzed Tandem Conjugate Addition-Electrophilic Trapping: Ketones, Esters, and Nitriles as Terminal Electrophiles [view]
Jim: Convenient Synthesis of Alkylhydrazides by the Cobalt-Catalyzed Hydrohydrazination Reaction of Olefins and Azodicarboxylates [view]

March 27
Beomjun: Total Synthesis of (+)-SCH351448 [view]

Jelena: Design, Synthesis, and in Vitro Biological Evaluation of Small Molecule Inhibitors of Estrogen Receptor CoactivatorBinding [view]
Tyler: Copper(II)-Catalyzed Highly Enantioselective Addition of Enamides to Imines: The Use of Enamides as Nucleophiles in Asymmetric Catalysis [view]
Michel: A Tandem Semipinacol Rearrangement/Alkylation of α-Epoxy Alcohols: An Efficient and Stereoselective Approach to Multifunctional 1,3-Diols [view]
Mike: Synthesis of Substituted Imidazoles via Organocatalysis [view]
Chris: Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide [view]

February 21
Corey: A Tandem Epoxidation/Stereoselective Intramolecular [4+3] Cycloaddition Reaction Involving Nitrogen-Stabilized Oxyallyl Cations Derived from Chiral Allenamides [view]
Rob: Suzuki Cross-Couplings of Unactivated Secondary Alkyl Bromides and Iodides [view]
Jaehyeon: Stereochemistry of Cyclopropane Formation Involving Group IV Organometallic Complexes [view]
Thomas: Metal-Catalyzed Di-tert-butylsilylene Transfer: Synthesis and Reactivity of Silacyclopropanes [view]
Claire: Polymer-Assisted, Multi-Step Solution Phase Synthesis and Biological Screening of Histone Deacetylase Inhibitors [view]

January 10
Steve: Catalytic Asymmetric Total Syntheses of Quinine and Quinidine [view]
Tamara: Enantioselective Access to 2,7-Cis-Disubstituted Oxepanes: Formal Synthesis of (+)-Isolaurepan [view]
Bryan: Heterobimetallic Catalysis in Asymmetric 1,4-Addition of O-Alkylhydroxylamine to Enones [view]
Jingbo: One-Pot Synthesis of Nitrogen Heterocycles Initiated by Regio and Diastereoselective Carbon-Carbon Bond Formation of Bifunctional Carbonyl Compounds [view]
Erick: Palladium-Catalyzed Multicomponent Coupling of Alkynes, Imines, and Acid Chlorides: A Direct and Modular Approach to Pyrrole Synthesis [view]


December 20
Jim: Synthesis of Optically Pure Arylsilylcarbinols and their Use as Chiral Auxiliaries in Oxacarbenium Ion Reactions [view]

Gil: Diversity-Oriented Synthesis of Tamoxifen-type Tetrasubstituted Olefins [view]
David: Diastereoselective Formation of 7-Membered Oxacycles by Ring-Expansion of Cyclopropanated Galactal [view]
Nilu: One-Pot Three-Component Tandem Metathesis/Diels-Alder Reaction [view]
Erika: Palladium-Imidazolium N-Heterocyclic Carbene- Catalyzed Carbonylative Amidation with Boronic Acids, Aryl Diazonium Ions and Ammonia [view]
Se-Ho: A Stereoselective Synthesis of (-)-Tetrodotoxin [view]

November 8
Chris: Synthesis of Cyclic and Acyclic b-Amino Acids via Chelation-Controlled 1,3-Dipolar Cycloaddition [view]
Beomjun: Diversity Synthesis via C-H Bond Functionalization: Concept Guided Development of New C-Arylation Methods for Imidazoles [view]

Mike: The First Catalytic, Asymmetric a-Additions of Isocyanides. Lewis-Base-Catalyzed, Enantioselective Passerini-Type Reactions [view]
Jelena: Scalability of Microwave-Assisted Organic Synthesis. From Single-Mode to Multimode Parallel Batch Reactors [view]

September 27
Rob: Stachybotrys Metabolites: A History of Mis-Identification [view]
Corey: Partitioning the Loss in Vancomycin Binding Affinity for D-Ala-D-Lac into Lost H-Bond and Repulsive Lone Pair Contributions [view]
Claire: The Direct and Enantioselective Organocatalytic a-Oxidation of Aldehydes [view]
Jaehyeon: Ligand-Free Heck Reaction: Pd(OAc)2 as an Active Catalyst Revisited [view]
Tom: Asymmetric Hydrosilylation of Aryl Ketones Catalyzed by Copper Hydride Complexed by Nonracemic Biphenyl Bis-Phospine Ligands [view]

August 30
Jingbo: A Heterocyclic Nanotube [view]
Nilu: "Mix and Shake" Method for Configurational Assignment by NMR: Application to Chiral Amines and Alcohols [view]
Tamara: Formal Synthesis of (-)-Apicularen [view]
Yasunori: Lewis Acid-Catalyzed Benzannulation via unprecedented [4+2] Cycloaddition of o-Alkynyl(oxo)benzenes and Enynals with Alkynes [view]
Bryan: A General Model for Selectivity in Olefin Cross Metathesis [view]

July 5
Se-Ho: Tandem Polar/Radical Crossover Sequences for the Formation of Fused and Bicyclic Nitrogen Heterocycles Involving Radical Ion Chain... [view]
Steve: Sulfur Ylides via Decarboxylation of Carboxymethylsulfonium Betaines: A Novel and Mild Protocol for the Preparation of Oxiranes [view]
Gil: Asymmetric Schmidt Reaction of Hydroxyalkyl Azides with Ketones [view]
Dave: Addition of Aldehydes and their Equivalents to Electron-Deficient Alkenes using N-Hydroxyphthalimide (NHPI) as a Polarity-Reversal Catalyst [view]
Erika: Hypervalent Iodine(II) Reagents as Safe Alternatives to alpha-Nitro-alpha-diazocarbonyls [view]
Jim: Lewis Base Activation of Lewis Acids: Vinylogous Aldol Reactions [view]