Research & Publications Updates
The Wipf Group research program focuses on:
• total synthesis of natural products
• organometallic and heterocyclic methodology development
• medicinal chemistry
• computational prediction of macroscopic properties as well as molecular
modeling
For recent examples of research projects of specific group members, please browse the publication records shown below. For a pdf reference file of all Wipf Group papers from 1990-2016, please click here.
| 2016 | Co-Worker | Publication 1 | Publication 2 | Publication 3 | Conference Presentations & Patents |
| Raffaele Colombo | "Optimization of Pyrazole-Containing 1,2,4-Triazolo-[3,4-B]Thiadiazines, a New Class of STAT3 Pathway Inhibitors." Laporte, M. G.; Wang, Z.; Colombo, R.; Garzan, A.; Peshkov, V. A.; Liang, M.; Johnston, P. A.; Schurdak, M. E.; Sen, M.; Camarco, D. P.; Hua, Y.; Pollock, N. I.; Lazo, J. S.; Grandis, J. R.; Wipf, P.; Huryn, D. M. Bioorg. Med. Chem. Lett. 2016, 26, 3581-3585. |
"Total Synthesis and Biological Evaluation of Tubulysin Analogues." Colombo, R.; Wang, Z.; Han, J.; Balachandran, R.; Daghestani, H. N.; Camarco, D. P.; Vogt, A.; Day, B. W.; Mendel, D.; Wipf, P. J. Org. Chem. (Special Issue on Heterocycles)2016, 81(21), 10302-10320. |
4 | ||
| Joe Salamoun | "Allosteric Modulation of Phosphatase Activity May Redefine Therapeutic Value." Salamoun, J. M.; Wipf, P. J. Med. Chem. 2016, 59(17), 7771-7772. |
"Photooxygenation of an Amino-Thienopyridone Yields a More Potent PTP4A3 Inhibitor." Salamoun, J. M.; McQueeney, K. E.; Patil, K.; Geib, S. J.; Sharlow, E. R.; Lazo, J. S.; Wipf, P. Org. Biomol. Chem. 2016, 14, 6398-6402. |
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| Matt LaPorte | "Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway." Alverez, C.; Bulfer, S. L.; Chakrasali, R.; Chimenti, M. S.; Deshaies, R. J.; Green, N.; Kelly, M.; Laporte, M. G.; Lewis, T. S.; Liang, M.; Moore, W. J.; Neitz, R. J.; Peshkov, V. A.; Walters, M. A.; Zhang, F.; Arkin, M. R.; Wipf, P.; Huryn, D. M. ACS Med. Chem. Lett. 2016, 7, 182-187. |
"Optimization of Pyrazole-Containing 1,2,4-Triazolo-[3,4-B]Thiadiazines, a New Class of STAT3 Pathway Inhibitors." Laporte, M. G.; Wang, Z.; Colombo, R.; Garzan, A.; Peshkov, V. A.; Liang, M.; Johnston, P. A.; Schurdak, M. E.; Sen, M.; Camarco, D. P.; Hua, Y.; Pollock, N. I.; Lazo, J. S.; Grandis, J. R.; Wipf, P.; Huryn, D. M. Bioorg. Med. Chem. Lett. 2016, 26, 3581-3585. | 2 | ||
| Mary Liang | "Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway." Alverez, C.; Bulfer, S. L.; Chakrasali, R.; Chimenti, M. S.; Deshaies, R. J.; Green, N.; Kelly, M.; Laporte, M. G.; Lewis, T. S.; Liang, M.; Moore, W. J.; Neitz, R. J.; Peshkov, V. A.; Walters, M. A.; Zhang, F.; Arkin, M. R.; Wipf, P.; Huryn, D. M. ACS Med. Chem. Lett. 2016, 7, 182-187. |
"Optimization of Pyrazole-Containing 1,2,4-Triazolo-[3,4-B]Thiadiazines, a New Class of STAT3 Pathway Inhibitors." Laporte, M. G.; Wang, Z.; Colombo, R.; Garzan, A.; Peshkov, V. A.; Liang, M.; Johnston, P. A.; Schurdak, M. E.; Sen, M.; Camarco, D. P.; Hua, Y.; Pollock, N. I.; Lazo, J. S.; Grandis, J. R.; Wipf, P.; Huryn, D. M. Bioorg. Med. Chem. Lett. 2016, 26, 3581-3585. |
2 | ||
| John Milligan | "Hydrophosphination of Bicyclo[1.1.0]butane-1-carbonitriles". Milligan, J. A.; Busacca, C. A.; Senanayake, C. H.; Wipf, P. Org. Lett. 2016, 18(17), 4300-4303. |
"Click Chemistry: Straining to React." Milligan, J. A.; Wipf, P. Nat. Chem. 2016, 8, 296-297. | 1 | ||
| Vsevolod Peshkov | "Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway." Alverez, C.; Bulfer, S. L.; Chakrasali, R.; Chimenti, M. S.; Deshaies, R. J.; Green, N.; Kelly, M.; Laporte, M. G.; Lewis, T. S.; Liang, M.; Moore, W. J.; Neitz, R. J.; Peshkov, V. A.; Walters, M. A.; Zhang, F.; Arkin, M. R.; Wipf, P.; Huryn, D. M. ACS Med. Chem. Lett. 2016, 7, 182-187. |
"Optimization of Pyrazole-Containing 1,2,4-Triazolo-[3,4-B]Thiadiazines, a New Class of STAT3 Pathway Inhibitors." Laporte, M. G.; Wang, Z.; Colombo, R.; Garzan, A.; Peshkov, V. A.; Liang, M.; Johnston, P. A.; Schurdak, M. E.; Sen, M.; Camarco, D. P.; Hua, Y.; Pollock, N. I.; Lazo, J. S.; Grandis, J. R.; Wipf, P.; Huryn, D. M. Bioorg. Med. Chem. Lett. 2016, 26, 3581-3585. | |||
| Chaemin Lim | "A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis." Krainz, T.; Gaschler, M. M.; Lim, C.; Sacher, J. R.; Stockwell, B. R.; Wipf, P. ACS Cent. Sci. 2016, 2(9), 653-659. |
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| Celeste Alverez | "Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway." Alverez, C.; Bulfer, S. L.; Chakrasali, R.; Chimenti, M. S.; Deshaies, R. J.; Green, N.; Kelly, M.; Laporte, M. G.; Lewis, T. S.; Liang, M.; Moore, W. J.; Neitz, R. J.; Peshkov, V. A.; Walters, M. A.; Zhang, F.; Arkin, M. R.; Wipf, P.; Huryn, D. M. ACS Med. Chem. Lett. 2016, 7, 182-187. |
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| Erin Skoda | "Small Molecule Antagonists of the Nuclear Androgen Receptor for the Treatment of Castration-Resistant Prostate Cancer." Johnson, J. K.; Skoda, E. M.; Zhou, J.; Parrinello, E.; Wang, D.; O'Malley, K.; Eyer, B. R.; Kazancioglu, M. Z.; Eisermann, K.; Johnston, P. A.; Nelson, J. B.; Wang, Z.; Wipf, P. ACS Med. Chem. Lett. 2016, 7(8), 785-790. |
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2 | ||
| James Johnson | "Small Molecule Antagonists of the Nuclear Androgen Receptor for the Treatment of Castration-Resistant Prostate Cancer." Johnson, J. K.; Skoda, E. M.; Zhou, J.; Parrinello, E.; Wang, D.; O'Malley, K.; Eyer, B. R.; Kazancioglu, M. Z.; Eisermann, K.; Johnston, P. A.; Nelson, J. B.; Wang, Z.; Wipf, P. ACS Med. Chem. Lett. 2016, 7(8), 785-790. |
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| Taber Lewis | "Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway." Alverez, C.; Bulfer, S. L.; Chakrasali, R.; Chimenti, M. S.; Deshaies, R. J.; Green, N.; Kelly, M.; Laporte, M. G.; Lewis, T. S.; Liang, M.; Moore, W. J.; Neitz, R. J.; Peshkov, V. A.; Walters, M. A.; Zhang, F.; Arkin, M. R.; Wipf, P.; Huryn, D. M. ACS Med. Chem. Lett. 2016, 7, 182-187. |
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| Yongzhao Yan | "2.3 Å Resolution Cryo-EM Structure of Human p97 and Mechanism of Allosteric Inhibition." Banerjee, S.; Bartesaghi, A.; Merk, A.; Rao, P.; Bulfer, S. L.; Yan, Y.; Green, N.; Mroczkowski, B.; Neitz, R. J.; Wipf, P.; Falconieri, V.; Deshaies, R. J.; Milne, J. L. S.; Huryn, D.; Arkin, M.; Subramaniam, S. Science 2016, 351(6275), 871-875. |
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| Alex Manos-Turvey | "Dihydropyrimidinones and -Thiones With Improved Activity Against Human Polyomavirus Family Members." Manos-Turvey, A.; Al-Ashtal, H. A.; Needham, P. G.; Hartline, C. B.; Prichard, M. N.; Wipf, P.; Brodsky, J. L. Bioorg. Med. Chem. Lett. 2016, 26, 5087-5091. | ||||
| Ben Eyer | "Small Molecule Antagonists of the Nuclear Androgen Receptor for the Treatment of Castration-Resistant Prostate Cancer." Johnson, J. K.; Skoda, E. M.; Zhou, J.; Parrinello, E.; Wang, D.; O'Malley, K.; Eyer, B. R.; Kazancioglu, M. Z.; Eisermann, K.; Johnston, P. A.; Nelson, J. B.; Wang, Z.; Wipf, P. ACS Med. Chem. Lett. 2016, 7(8), 785-790. | ||||
| Atefeh Garzan | "Optimization of Pyrazole-Containing 1,2,4-Triazolo-[3,4-B]Thiadiazines, a New Class of STAT3 Pathway Inhibitors." Laporte, M. G.; Wang, Z.; Colombo, R.; Garzan, A.; Peshkov, V. A.; Liang, M.; Johnston, P. A.; Schurdak, M. E.; Sen, M.; Camarco, D. P.; Hua, Y.; Pollock, N. I.; Lazo, J. S.; Grandis, J. R.; Wipf, P.; Huryn, D. M. Bioorg. Med. Chem. Lett. 2016, 26, 3581-3585. | ||||
| Josh Sacher | "A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis." Krainz, T.; Gaschler, M. M.; Lim, C.; Sacher, J. R.; Stockwell, B. R.; Wipf, P. ACS Cent. Sci. 2016, 2(9), 653-659. |
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| Junyan Han | "Total Synthesis and Biological Evaluation of Tubulysin Analogues." Colombo, R.; Wang, Z.; Han, J.; Balachandran, R.; Daghestani, H. N.; Camarco, D. P.; Vogt, A.; Day, B. W.; Mendel, D.; Wipf, P. J. Org. Chem. (Special Issue on Heterocycles)2016, 81(21), 10302-10320. | ||||
| Zhiyong Wang | "Total Synthesis and Biological Evaluation of Tubulysin Analogues." Colombo, R.; Wang, Z.; Han, J.; Balachandran, R.; Daghestani, H. N.; Camarco, D. P.; Vogt, A.; Day, B. W.; Mendel, D.; Wipf, P. J. Org. Chem. (Special Issue on Heterocycles)2016, 81(21), 10302-10320.. |
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| Mustafa Kazancioglu | "Small Molecule Antagonists of the Nuclear Androgen Receptor for the Treatment of Castration-Resistant Prostate Cancer." Johnson, J. K.; Skoda, E. M.; Zhou, J.; Parrinello, E.; Wang, D.; O'Malley, K.; Eyer, B. R.; Kazancioglu, M. Z.; Eisermann, K.; Johnston, P. A.; Nelson, J. B.; Wang, Z.; Wipf, P. ACS Med. Chem. Lett. 2016, 7(8), 785-790. |
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| Tanja Krainz | "A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis." Krainz, T.; Gaschler, M. M.; Lim, C.; Sacher, J. R.; Stockwell, B. R.; Wipf, P. ACS Cent. Sci. 2016, 2(9), 653-659. | ||||
| Steph McCabe | "Total Synthesis, Biosynthesis and Biological Profiles of Clavine Alkaloids." McCabe, S. R.; Wipf, P. Org. Biomol. Chem. 2016, 14, 5894-5913. | ||||
| Kalyani Patil | "Photooxygenation of an Amino-Thienopyridone Yields a More Potent PTP4A3 Inhibitor." Salamoun, J. M.; McQueeney, K. E.; Patil, K.; Geib, S. J.; Sharlow, E. R.; Lazo, J. S.; Wipf, P. Org. Biomol. Chem. 2016, 14, 6398-6402. | ||||
| Nic Reed | "Synthesis and Evaluation of Potent KCNQ2/3-specific Channel Activators." Kumar, M.; Reed, N.; Liu, R.; Aizenmann, E.; Wipf, P.; Tzounopoulos, T. Mol. Pharmacol. 2016, 89(6), 667-677. | ||||
| Ruiting Liu | "Synthesis and Evaluation of Potent KCNQ2/3-specific Channel Activators." Kumar, M.; Reed, N.; Liu, R.; Aizenmann, E.; Wipf, P.; Tzounopoulos, T. Mol. Pharmacol. 2016, 89(6), 667-677. | ||||
| Zhuzhu Wang | "Optimization of Pyrazole-Containing 1,2,4-Triazolo-[3,4-B]Thiadiazines, a New Class of STAT3 Pathway Inhibitors." Laporte, M. G.; Wang, Z.; Colombo, R.; Garzan, A.; Peshkov, V. A.; Liang, M.; Johnston, P. A.; Schurdak, M. E.; Sen, M.; Camarco, D. P.; Hua, Y.; Pollock, N. I.; Lazo, J. S.; Grandis, J. R.; Wipf, P.; Huryn, D. M. Bioorg. Med. Chem. Lett. 2016, 26, 3581-3585. | ||||
| Marina Kovaliov |
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| Zhizhou Yue |
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| Lalith Samankumara |
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| Alex Chatterley | 2 | ||||
| Michael Houghton |
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| Eric Miller | 1 |