Yasunori Aoyama

yasunori.aoyama@shionogi.co.jp
Yasunori77ao@aol.com

Postdoctoral Fellow The University of Pittsburgh, Pittsburgh, Pennsylvania, November 2002 - October 2003
Ph.D. (Chemistry) Kyoto University, Kyoto, Japan, 2002
Researcher Shionogi & Co., Ltd., Osaka, Japan, 1995-2002
M.S. (Chemistry) Kyoto University, Kyoto, Japan, 1995
B.S. (Chemistry) Kyoto University, Kyoto, Japan, 1992

Publications

Aoyama, Y.; Araki, Y.; Konoike, T. Stereoselective Total Synthesis of (–)-a-Eudesmol, a P/Q-Type Calcium Channel Blocker, Synlett. 2001, 9, 1452-1454
Aoyama, Y. Non-peptidic Chymase Inhibitors , Expert Opinion on Therapeutic Patents, 2001, 11, 1423-1428.
Aoyama, Y.; Uenaka, M.; Konoike, T.; Hayasaki-Kajiwara, Y.; Naya, N.; Nakajima, M. Inhibition of Serine Proteases: Activity of 1,3-Diazetidine-2,4-Diones, Bioorg. Med. Chem. Lett. 2001, 11, 1691-1694.
Aoyama, Y.; Konoike, T.; Kanda, A.; Naya, N.; Nakajima, M. Total Synthesis of Human Chymase Inhibitor Methyllinderone and Structure-Activity Relationships of Its Derivatives, Bioorg. Med. Chem. Lett. 2001, 11, 1695-1697.
Aoyama, Y.; Uenaka, M.; Kii, M.; Tanaka, M.; Konoike, T.; Hayasaki-Kajiwara, Y.; Naya, N.; Nakajima, M. Design, Synthesis and Pharmacological Evaluation of 3-Benzylazetidine-2-one-Based Human Chymase Inhibitors, Bioorg. Med. Chem. 2001, 9, 3065-3075.
Shirai, K.; Hamamoto, T.; Maki, T.; Onomura, O.; Kise, N.; Aoyama, Y.; Matsumura, Y. Effects of Trifluoroethanol as a Co-Solvent on the Electrochemical Oxidation of Hardly Oxidizable Organic Compounds, Jouranal of Electroanalytical Chemistry 2001, 507, 191-197.
Aoyama, Y.; Uenaka, M.; Konoike, T.; Iso, Y.; Nishitani, Y.; Kanda, A.; Naya, N.; Nakajima, M. Synthesis and Structure-Activity Relationships of a New Class of 1-Oxacephem-Based Human Chymase Inhibitors. Bioorg. Med. Chem. Lett. 2000, 10, 2397-2401.
Aoyama, Y.; Uenaka, M.; Konoike, T.; Iso, Y.; Nishitani, Y.; Kanda, A.; Naya, N.; Nakajima, M. 1-Oxacephem-Based Human Chymase Inhibitors: Discovery of Stable Inhibitors in Human Plasma, Bioorg. Med. Chem. Lett. 2000, 10, 2403-2406.
Hayashi, T.; Takimura, T.; Aoyama, Y.; Hitomi, Y.; Suzuki, A.; Ogoshi, H. Structure and Reactivity of Reconstituted Myoglobins: Interaction between Protein and Polar Side Chain of Chemically Modified Hemin, Inorganica Chimica Acta 1998, 275-276, 159-167.
Matsumura, Y.; Nishimura, M.; Watanabe, M.; Kise, N.; Aoyama, Y.; Kashimura, S. Stereoselective Homocoupling of Phenylacetic Acid Derivatives Utilizing Electrochemically Generated Base, Electrochimica Acta 1997, 42, 2233-2239.
Kise, N.; Tokioka, K.; Aoyama, Y.; Matsumura, Y. Enantioselective Synthesis of 2,3-Disubstituted Succinic Acids by Oxidative Homocoupling of Optically Active 3-Acyl-2-oxazolidones, J. Org. Chem. 1995, 60, 1100-1101.
Hayashi, T.; Miyahara, T.; Aoyama, Y.; Kobayashi, M.; Ogoshi, H. Intermolecular Interaction between Multifunctional Porphyrin and Ubiquinone Analogues, Pure & Appl. Chem. 1994, 66, 797-802.
Hayashi, T.; Miyahara, T.; Aoyama, Y.; Nonoguchi, M. Ogoshi, H. Preparation and Binding Affinity of New Porphyrin Host Molecule for Ubiquinone Analogues, Chem. Lett. 1994, 1749-1752.