Definition of a Compound Probe:

The minimum properties displayed by a compound to be defined as a compound probe are:

    1. Potency: <1 – 10 uM; context dependent (varies with assay target & current state of the art; example: new compound provides similar potency but improved selectivity)
    2. Solubility: sufficient solubility in relevant assay solvents.
    3. Availability:  accessible in amounts to allow advanced studies (15-20 mg)

Development of a new probe: must represent an improvement over the existing art.