Publications

Optimization of Pyrazole-containing 1,2,4-Triazolo-[3,4-b]thiadiazines, a New Class of STAT3 Pathway Inhibitors
Matthew G. LaPorte, Zhuzhu Wang, Raffaele Colombo, Atefeh Garzan, Vsevolod A. Peshkov, Mary Liang, Paul A. Johnston, Mark E. Schurdak, Malabika Sen, Daniel P. Camarco, Yun Hua, Netanya I. Pollock, John S. Lazo, Jennifer R. Grandis, Peter Wipf, Donna M. Huryn, Bioorganic & Medicinal Chemistry Letters 2016, in press. DOI: 10.1016/j.bmcl.2016.06.017

2.3 Å Resolution Cryo-EM Structure of Human p97 and Mechanism of Allosteric Inhibition
Banerjee, S.; Bartesaghi, A.; Merk, A.; Rao, P.; Bulfer S. L.; Yan, Y.; Green, N.; Mroczkowski, B.; Neitz, R. J.; Wipf, P.; Falconieri, V.; Deshaies R. J.; Milne J, L. S.; Huryn, D.; Arkin, M.; Subramaniam, S. Science 2016, 351, 871-5. DOI: 10.1126/science.aad7974

Allosteric indole amide inhibitors of p97: Identification of a novel probe of the ubiquitin pathway
Alverez, C.; Bulfer, S. L.; Chakrasali, R.; Chimenti, M. S.; Deshaies, R. J.; Green, N.; Kelly, M.; Laporte, M. G.; Lewis, T. S.; Liang, M.; Moore, W. J.; Neitz, R. J.; Peshkov, V. A.; Walters, M. A.; Zhang, F.; Arkin, M. R.; Wipf, P.; Huryn, D. M. ACS Med. Chem. Lett. 2016, 7, 182-187. DOI: 10.1021/acsmedchemlett.5b00396

HCS Campaign to Identify Selective Inhibitors of IL-6-Induced STAT3 Pathway Activation in Head and Neck Cancer Cell Lines
Johnston, P. A.; Sen, M.; Hua, Y.; Camarco, D. P.; Shun, T. Y.; Lazo, J. S.; Wilson, G. M.; Resnick, L. O.; La Porte, M. G.; Wipf, P.; Huryn, D. M.; Grandis, J. R., "Hcs campaign to identify selective inhibitors of il-6-induced stat3 pathway activation in head and neck cancer cell lines." Assay and Drug Development Technologies 2015, 13, 356-376. doi:10.1089/adt.2015.663

Structure–Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97
Celeste Alverez, Michelle R. Arkin, Stacie L. Bulfer, Raffaele Colombo, Marina Kovaliov, Matthew G. LaPorte, Chaemin Lim, Mary Liang, William J. Moore, R. Jeffrey Neitz, Yongzhao Yan, Zhizhou Yue, Donna M. Huryn, and Peter Wipf. ACS Med. Chem. Lett. 2015, 6, 1225-1230. DOI: 10.1021/acsmedchemlett.5b00364

2-Guanidinoquinazolines as New Inhibitors of the STAT3 Pathway
LaPorte, M. G.; da Paz Lima, D. J.; Zhang F.; Sen M.; Grandis, J. R.; Camarco, D., Hua; Y, Johnston, P. A.; Lazo, J. S.; Resnick, L. O.; Wipf, P.; Huryn, D. M. Bioorg. Med. Chem. Lett. 2014, 24, 5081-5085. http://www.ncbi.nlm.nih.gov/pubmed/25288188

A New Synthesis of 4,5,6,7-Tetrahydropyrazolo[1,5-c]pyrimidines by a Retro-Mannich Cascade Rearrangement
Colombo, R.; Jeon, K. O.; Huryn, D. M.; LaPorte, M. G.; Wipf, P. Austr. J. Chem. 2014, 67, 420-425. http://www.publish.csiro.au/paper/CH13468.htm

Contributions of Academic Laboratories to the Discovery and Development of Chemical Biology Tools
Huryn, D. M.; Resnick, L. O.; Wipf, P. J Med. Chem. 2013, 56, 7161-7176. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785552

Drug Discovery in an Academic Setting: Playing to the Strengths
Huryn, D. H. ACS Med. Chem. Lett. 2013, 4, 313-315. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027497

The CBC & Pitt: Chemical Diversity & Specialized Applications 2010 AACI/CCAF meeting, October 4, 2010, Chicago.